Paul J Lombroso
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Explore the profile of Paul J Lombroso including associated specialties, affiliations and a list of published articles.
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102
Citations
4226
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Recent Articles
1.
Dedek A, Xu J, Lorenzo L, Godin A, Kandegedara C, Glavina G, et al.
Brain
. 2022 Mar;
145(3):1124-1138.
PMID: 35323848
The prevalence and severity of many chronic pain syndromes differ across sex, and recent studies have identified differences in immune signalling within spinal nociceptive circuits as a potential mediator. Although...
2.
Lambert L, Grotegut S, Celeridad M, Gosalia P, Backer L, Bobkov A, et al.
Int J Mol Sci
. 2021 Apr;
22(9).
PMID: 33922601
Many human diseases are the result of abnormal expression or activation of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). Not surprisingly, more than 30 tyrosine kinase inhibitors (TKIs)...
3.
Chatterjee M, Kwon J, Benedict J, Kamceva M, Kurup P, Lombroso P
Exp Brain Res
. 2021 Jan;
239(3):881-890.
PMID: 33420799
Loss of dendritic spines and decline of cognitive function are hallmarks of patients with Alzheimer's disease (AD). Previous studies have shown that AD pathophysiology involves increased expression of a central...
4.
Chatterjee M, Singh P, Xu J, Lombroso P, Kurup P
Behav Brain Res
. 2020 May;
391:112713.
PMID: 32461127
Autism spectrum disorders (ASDs) are highly prevalent childhood illnesses characterized by impairments in communication, social behavior, and repetitive behaviors. Studies have found aberrant synaptic plasticity and neuronal connectivity during the...
5.
Mallozzi C, Pepponi R, Visentin S, Chiodi V, Lombroso P, Bader M, et al.
J Neurochem
. 2019 Sep;
152(3):284-298.
PMID: 31520531
We recently demonstrated that a tonic activation of adenosine A receptors (A Rs) is required for cocaine-induced synaptic depression and increase in the activity of STriatal-Enriched protein tyrosine Phosphatase (STEP)....
6.
Dedek A, Xu J, Kandegedara C, Lorenzo L, Godin A, De Koninck Y, et al.
Brain
. 2019 May;
142(6):1535-1546.
PMID: 31135041
Dysregulated excitability within the spinal dorsal horn is a critical mediator of chronic pain. In the rodent nerve injury model of neuropathic pain, BDNF-mediated loss of inhibition (disinhibition) gates the...
7.
Castonguay D, Dufort-Gervais J, Menard C, Chatterjee M, Quirion R, Bontempi B, et al.
Curr Biol
. 2018 Mar;
28(7):1079-1089.e4.
PMID: 29576474
Cognitive disabilities that occur with age represent a growing and expensive health problem. Age-associated memory deficits are observed across many species, but the underlying molecular mechanisms remain to be fully...
8.
Chandra Tjin C, Otley K, Baguley T, Kurup P, Xu J, Nairn A, et al.
ACS Cent Sci
. 2018 Jan;
3(12):1322-1328.
PMID: 29296673
Dysregulation of protein tyrosine phosphorylation has been implicated in a number of human diseases, including cancer, diabetes, and neurodegenerative diseases. As a result of their essential role in regulating protein...
9.
Witten M, Wissler L, Snow M, Geschwindner S, Read J, Brandon N, et al.
J Med Chem
. 2017 Nov;
60(22):9299-9319.
PMID: 29116812
Excessive activity of striatal-enriched protein tyrosine phosphatase (STEP) in the brain has been detected in numerous neuropsychiatric disorders including Alzheimer's disease. Notably, knockdown of STEP in an Alzheimer mouse model...
10.
Lombroso P, Ogren M, Kurup P, Nairn A
F1000Res
. 2017 Nov;
5.
PMID: 29098072
This commentary focuses on potential molecular mechanisms related to the dysfunctional synaptic plasticity that is associated with neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. Specifically, we focus on...