Lih-Yun Hsu
Overview
Explore the profile of Lih-Yun Hsu including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
13
Citations
767
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Ashouri J, Hsu L, Yu S, Rychkov D, Chen Y, Cheng D, et al.
Proc Natl Acad Sci U S A
. 2019 Aug;
116(37):18517-18527.
PMID: 31455730
How pathogenic cluster of differentiation 4 (CD4) T cells in rheumatoid arthritis (RA) develop remains poorly understood. We used Nur77-a marker of T cell antigen receptor (TCR) signaling-to identify antigen-activated...
2.
Hsu L, Cheng D, Chen Y, Liang H, Weiss A
J Exp Med
. 2017 Feb;
214(3):833-849.
PMID: 28159798
Zap70 plays a critical role in normal T cell development and T cell function. However, little is known about how perturbation of allosteric autoinhibitory mechanisms in Zap70 impacts T cell...
3.
van der Loeff I, Hsu L, Saini M, Weiss A, Seddon B
J Immunol
. 2014 Aug;
193(6):2873-80.
PMID: 25092893
Survival of naive T cells requires engagement of TCR with self-peptide major histocompatibility Ags. The signaling pathways required to transmit this survival signal are poorly understood. In this study, we...
4.
Charles J, Hsu L, Niemi E, Weiss A, Aliprantis A, Nakamura M
J Clin Invest
. 2012 Nov;
122(12):4592-605.
PMID: 23114597
Increased osteoclastic bone resorption leads to periarticular erosions and systemic osteoporosis in RA patients. Although a great deal is known about how osteoclasts differentiate from precursors and resorb bone, the...
5.
Au-Yeung B, Levin S, Zhang C, Hsu L, Cheng D, Killeen N, et al.
Nat Immunol
. 2010 Nov;
11(12):1085-92.
PMID: 21037577
To investigate the role of the kinase Zap70 in T cells, we generated mice expressing a Zap70 mutant whose catalytic activity can be selectively blocked by a small-molecule inhibitor. We...
6.
Wang H, Kadlecek T, Au-Yeung B, Goodfellow H, Hsu L, Freedman T, et al.
Cold Spring Harb Perspect Biol
. 2010 May;
2(5):a002279.
PMID: 20452964
ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of...
7.
Hsu L, Tan Y, Xiao Z, Malissen M, Weiss A
J Exp Med
. 2009 Oct;
206(11):2527-41.
PMID: 19841086
ZAP-70 is critical for T cell receptor (TCR) signaling. Tyrosine to phenylalanine mutations of Y315 and Y319 in ZAP-70 suggest these residues function to recruit downstream effector molecules, but mutagenesis...
8.
Au-Yeung B, Deindl S, Hsu L, Palacios E, Levin S, Kuriyan J, et al.
Immunol Rev
. 2009 Mar;
228(1):41-57.
PMID: 19290920
The tyrosine ZAP-70 (zeta-associated protein of 70 kDa) kinase plays a critical role in activating many downstream signal transduction pathways in T cells following T-cell receptor (TCR) engagement. The importance...
9.
Liang H, Hsu L, Cado D, Schlissel M
Cell
. 2004 Jul;
118(1):19-29.
PMID: 15242641
Regulated gene rearrangement is thought to underlie allelic exclusion, the observation that an individual B cell expresses only a single immunoglobulin molecule. Previous data has implicated transcriptional activation of rearranging...
10.
Hsu L, Liang H, Johnson K, Kang C, Schlissel M
J Exp Med
. 2004 Mar;
199(6):825-30.
PMID: 15007090
Mice deficient for the B cell-restricted transcription factor Pax5 show a defect in the VH to DJH rearrangement step of immunoglobulin heavy chain gene assembly even though the expression of...