Lih-Ling Lin
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Explore the profile of Lih-Ling Lin including associated specialties, affiliations and a list of published articles.
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53
Citations
1435
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Recent Articles
1.
Xu X, Yan S, Yo Y, Chiang P, Tsai C, Lin L, et al.
Cancers (Basel)
. 2024 Sep;
16(17).
PMID: 39272910
Programmed cell death 1 (PD-1) and programmed death-ligand 1 (PD-L1) interact to form an immune checkpoint fostering viral infection and viral oncogene-induced tumorigenesis. We generated a novel anti-human PD-1, humanized...
2.
Du G, Zhao L, Zheng Y, Belfetmi A, Cai T, Xu B, et al.
Cell Res
. 2023 Jan;
33(2):131-146.
PMID: 36604598
Members of the tumor necrosis factor receptor superfamily (TNFRSF) are important therapeutic targets that can be activated to induce death of cancer cells or stimulate proliferation of immune cells. Although...
3.
Liu C, Makrinioti H, Saglani S, Bowman M, Lin L, Camargo Jr C, et al.
Front Immunol
. 2022 Oct;
13:1028209.
PMID: 36248891
Asthma is a chronic and heterogeneous respiratory disease with many risk factors that typically originate during early childhood. A complex interplay between environmental factors and genetic predisposition is considered to...
4.
Zhu H, Galdos F, Lee D, Waliany S, Huang Y, Ryan J, et al.
Circulation
. 2022 Jun;
146(4):316-335.
PMID: 35762356
Background: Immune checkpoint inhibitors (ICIs) are monoclonal antibodies used to activate the immune system against tumor cells. Despite therapeutic benefits, ICIs have the potential to cause immune-related adverse events such...
5.
Wang H, Newton G, Wu L, Lin L, Miracco A, Natesan S, et al.
JCI Insight
. 2021 Sep;
6(21).
PMID: 34591795
Experimental autoimmune encephalomyelitis (EAE) is a well-characterized animal model of multiple sclerosis. During the early phase of EAE, infiltrating monocytes and monocyte-derived macrophages contribute to T cell recruitment, especially CD4+...
6.
Winkler A, Sun W, De S, Jiao A, Sharif M, Symanowicz P, et al.
Arthritis Rheumatol
. 2021 Aug;
73(12):2206-2218.
PMID: 34423919
Objective: To investigate the role of PF-06650833, a highly potent and selective small-molecule inhibitor of interleukin-1-associated kinase 4 (IRAK4), in autoimmune pathophysiology in vitro, in vivo, and in the clinical...
7.
Seyhan A, Gregory B, Cribbs A, Bhalara S, Li Y, Loreth C, et al.
Sci Rep
. 2020 Jun;
10(1):8830.
PMID: 32483203
We profiled gene expression signatures to distinguish rheumatoid arthritis (RA) from non-inflammatory arthralgia (NIA), self-limiting arthritis (SLA), and undifferentiated arthritis (UA) as compared to healthy controls as novel potential biomarkers...
8.
Cella M, Gamini R, Secca C, Collins P, Zhao S, Peng V, et al.
Nat Immunol
. 2019 Aug;
20(10):1405.
PMID: 31388149
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
9.
Cella M, Gamini R, Secca C, Collins P, Zhao S, Peng V, et al.
Nat Immunol
. 2019 Jun;
20(8):980-991.
PMID: 31209406
Innate lymphoid cells (ILCs) are tissue-resident lymphocytes categorized on the basis of their core regulatory programs and the expression of signature cytokines. Human ILC3s that produce the cytokine interleukin-22 convert...
10.
De S, Karim F, Kiessu E, Cushing L, Lin L, Ghandil P, et al.
J Biol Chem
. 2018 Aug;
293(39):15208-15220.
PMID: 30115681
Interleukin-1 receptor (IL1R)-associated kinase 4 (IRAK4) is a central regulator of innate immune signaling, controlling IL1R and Toll-like receptor (TLR)-mediated responses and containing both scaffolding and kinase activities. Humans deficient...