Liesbet Martens
Overview
Explore the profile of Liesbet Martens including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
3779
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Recent Articles
1.
De Ponti F, Bujko A, Liu Z, Collins P, Schuermans S, Maueroder C, et al.
Immunity
. 2025 Jan;
58(2):362-380.e10.
PMID: 39862865
Our understanding of the functional heterogeneity of resident versus recruited macrophages in the diseased liver is limited. A population of recruited lipid-associated macrophages (LAMs) has been reported to populate the...
2.
Perry A, Hadad N, Chatterjee E, Jimenez-Ramos M, Farber-Eger E, Roshani R, et al.
Cell Rep Med
. 2024 Dec;
5(12):101871.
PMID: 39657669
Hepatic steatosis is a central phenotype in multi-system metabolic dysfunction and is increasing in parallel with the obesity pandemic. We use a translational approach integrating clinical phenotyping and outcomes, circulating...
3.
Perry A, Hadad N, Chatterjee E, Ramos M, Farber-Eger E, Roshani R, et al.
medRxiv
. 2024 Feb;
PMID: 38352394
Metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence is increasing in parallel with an obesity pandemic, calling for novel strategies for prevention and treatment. We defined a circulating proteome of human...
4.
Van Damme K, Hoste L, Declercq J, De Leeuw E, Maes B, Martens L, et al.
Sci Transl Med
. 2023 Aug;
15(710):eadi0252.
PMID: 37611083
Improvements in COVID-19 treatments, especially for the critically ill, require deeper understanding of the mechanisms driving disease pathology. The complement system is not only a crucial component of innate host...
5.
Bosteels V, Marechal S, De Nolf C, Rennen S, Maelfait J, Tavernier S, et al.
Sci Immunol
. 2023 May;
8(83):eadd3955.
PMID: 37172103
Dendritic cells (DCs) mature in an immunogenic or tolerogenic manner depending on the context in which an antigen is perceived, preserving the balance between immunity and tolerance. Whereas the pathways...
6.
Bosteels C, Van Damme K, De Leeuw E, Declercq J, Maes B, Bosteels V, et al.
Cell Rep Med
. 2022 Dec;
3(12):100833.
PMID: 36459994
GM-CSF promotes myelopoiesis and inflammation, and GM-CSF blockade is being evaluated as a treatment for COVID-19-associated hyperinflammation. Alveolar GM-CSF is, however, required for monocytes to differentiate into alveolar macrophages (AMs)...
7.
Scheyltjens I, Van Hove H, De Vlaminck K, Kancheva D, Bastos J, Vara-Perez M, et al.
Nat Protoc
. 2022 Aug;
17(10):2354-2388.
PMID: 35931780
Brain-immune cross-talk and neuroinflammation critically shape brain physiology in health and disease. A detailed understanding of the brain immune landscape is essential for developing new treatments for neurological disorders. Single-cell...
8.
Kleinberger I, Sanders E, Staes K, Van Troys M, Hirano S, Hochepied T, et al.
BMC Cancer
. 2022 Apr;
22(1):451.
PMID: 35468745
Background: Nonclustered mouse protocadherin genes (Pcdh) encode proteins with a typical single ectodomain and a cytoplasmic domain with conserved motifs completely different from those of classic cadherins. Alternative splice isoforms...
9.
Guilliams M, Bonnardel J, Haest B, Vanderborght B, Wagner C, Remmerie A, et al.
Cell
. 2022 Jan;
185(2):379-396.e38.
PMID: 35021063
The liver is the largest solid organ in the body, yet it remains incompletely characterized. Here we present a spatial proteogenomic atlas of the healthy and obese human and murine...
10.
Geeraerts X, Fernandez-Garcia J, Hartmann F, de Goede K, Martens L, Elkrim Y, et al.
Cell Rep
. 2021 Dec;
37(13):110171.
PMID: 34965415
Macrophages are often prominently present in the tumor microenvironment, where distinct macrophage populations can differentially affect tumor progression. Although metabolism influences macrophage function, studies on the metabolic characteristics of ex ...