Lidija Covic
Overview
Explore the profile of Lidija Covic including associated specialties, affiliations and a list of published articles.
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53
Citations
2248
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Recent Articles
11.
McAuley J, Bailey K, Ekambaram P, Klei L, Kang H, Hu D, et al.
Oncogene
. 2019 Aug;
38(49):7384-7398.
PMID: 31420608
Protease-activated receptor 1 (PAR1), a thrombin-responsive G protein-coupled receptor (GPCR), is implicated in promoting metastasis in multiple tumor types, including both sarcomas and carcinomas, but the molecular mechanisms responsible remain...
12.
Kimmelstiel C, Stevenson R, Nguyen N, Van Doren L, Zhang P, Perkins J, et al.
Thromb Res
. 2019 Mar;
177:59-69.
PMID: 30851630
ACS patients undergoing percutaneous coronary intervention (PCI) when treated with bivalirudin and clopidogrel had increased frequency of early stent thrombosis. 24 patients referred for intervention with planned bivalirudin therapy, not...
13.
Michael E, Covic L, Kuliopulos A
J Biol Chem
. 2019 Jan;
294(12):4401-4411.
PMID: 30670596
Pancreatic β-cell failure in type 2 diabetes mellitus is a serious challenge that results in an inability of the pancreas to produce sufficient insulin to properly regulate blood glucose levels....
14.
Barr T, Garzia C, Guha S, Fletcher E, Nguyen N, Wieschhaus A, et al.
J Invest Dermatol
. 2018 Oct;
139(2):412-421.
PMID: 30287285
PAR2 has been proposed to contribute to lesion formation and intense itch in atopic dermatitis. Here, we tested the ability of a cell-penetrating pepducin, PZ-235, to mitigate the potentially deleterious...
15.
Covic L, Kuliopulos A
Int J Mol Sci
. 2018 Aug;
19(8).
PMID: 30065181
The G-protein coupled receptors (GPCRs) belong to a large family of diverse receptors that are well recognized as pharmacological targets. However, very few of these receptors have been pursued as...
16.
Rana R, Huang T, Koukos G, Fletcher E, Turner S, Shearer A, et al.
Arterioscler Thromb Vasc Biol
. 2018 Apr;
38(6):1368-1380.
PMID: 29622563
Objective: Protease-activated receptor-1 (PAR1) is classically activated by thrombin and is critical in controlling the balance of hemostasis and thrombosis. More recently, it has been shown that noncanonical activation of...
17.
Shearer A, Rana R, Austin K, Baleja J, Nguyen N, Bohm A, et al.
J Biol Chem
. 2016 Sep;
291(44):23188-23198.
PMID: 27613872
Chronic liver inflammation and fibrosis in nonalcoholic steatohepatitis can lead to cirrhosis and liver failure for which there are currently no approved treatments. Protease-activated receptor-2 (PAR2) is an emerging new...
18.
Gurbel P, Bliden K, Turner S, Tantry U, Gesheff M, Barr T, et al.
Arterioscler Thromb Vasc Biol
. 2015 Dec;
36(1):189-97.
PMID: 26681756
Objective: Pepducins are membrane-tethered, cell-penetrating lipopeptides that target the cytoplasmic surface of their cognate receptor. Here, we report the first human use of a protease-activated receptor-1-based pepducin, which is intended...
19.
Zhang P, Covic L, Kuliopulos A
Methods Mol Biol
. 2015 Jul;
1324:191-203.
PMID: 26202271
Lipopeptides based on the intracellular loops of cell-surface receptors, known as "Pepducins," represent a promising new class of compounds used for the study of membrane proteins and as potential therapeutics...
20.
Zhang P, Leger A, Baleja J, Rana R, Corlin T, Nguyen N, et al.
J Biol Chem
. 2015 May;
290(25):15785-15798.
PMID: 25934391
G protein-coupled receptors (GPCRs) are remarkably versatile signaling systems that are activated by a large number of different agonists on the outside of the cell. However, the inside surface of...