Liao Y Chen
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Explore the profile of Liao Y Chen including associated specialties, affiliations and a list of published articles.
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Articles
35
Citations
237
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Recent Articles
1.
Renthal R, Chen L
Biophys Chem
. 2022 Aug;
289:106862.
PMID: 35933834
MhOR5, an insect olfactory receptor (OR), has an occluded binding site for the odorant eugenol in both the open and closed states of the ion channel. We used atomistic molecular...
2.
Chen L
Biochim Biophys Acta Biomembr
. 2022 Jun;
1864(9):183975.
PMID: 35654150
Glucose transporter GLUT1 is ubiquitously expressed in the human body from the red cells to the blood-brain barrier to the skeletal muscles. It is physiologically relevant to understand how GLUT1...
3.
Falato M, Chan R, Chen L
RSC Adv
. 2022 Feb;
12(5):3128-3135.
PMID: 35222995
AQP7 is one of the four human aquaglyceroporins that facilitate glycerol transport across the cell membrane, a biophysical process that is essential in human physiology. Therefore, it is interesting to...
4.
Xu L, Chen L
Biophys Chem
. 2022 Feb;
283:106765.
PMID: 35101818
Dopamine transporter mediates the neurotransmitter dopamine homeostasis in a sodium-dependent manner. The transport process involves an alternating access of a substrate to the extracellular and intracellular spaces, which is associated...
5.
Xu L, Phelix C, Chen L
J Chem Inf Model
. 2021 Oct;
61(11):5614-5625.
PMID: 34664967
Pyruvate metabolism requires the mitochondrial pyruvate carrier (MPC) proteins to transport pyruvate from the intermembrane space through the inner mitochondrial membrane to the mitochondrial matrix. The lack of the atomic...
6.
Xu L, Chen L
Chem Biol Drug Des
. 2021 Mar;
97(6):1194-1209.
PMID: 33754484
Dopamine transporter (DAT) and sigma-1 receptor (σ1R) are potential therapeutic targets to reduce the psychostimulant effects induced by methamphetamine (METH). Interaction of σ1R with DAT could modulate the binding of...
7.
Xu L, Chen L
Sci Rep
. 2020 Dec;
10(1):22267.
PMID: 33335233
Cytochrome P450 2J2 (CYP2J2) is responsible for the epoxidation of endogenous arachidonic acid, and is involved in the metabolism of exogenous drugs. To date, no crystal structure of CYP2J2 is...
8.
Rodriguez R, Chan R, Liang H, Chen L
RSC Adv
. 2020 Sep;
10(56):34203-34214.
PMID: 32944226
The structures of several aquaglyceroporins have been resolved to atomic resolution showing two or more glycerols bound inside a channel and confirming a glycerol-facilitator's affinity for its substrate glycerol. However,...
9.
Xu L, Chen L
J Chem Inf Model
. 2020 Jul;
60(8):3958-3968.
PMID: 32649824
Dopamine (DA) transporter (DAT) is a major target for psychostimulant drugs of abuse such as cocaine that competitively binds to DAT, inhibits DA reuptake, and consequently increases synaptic DA levels....
10.
Chan R, Falato M, Liang H, Chen L
RSC Adv
. 2020 Jul;
10(36):21283-21291.
PMID: 32612811
Modelling water and membrane lipids is an essential element in the computational research of biophysical/biochemical processes such as water transport across the cell membrane. In this study, we examined the...