Clyde F Phelix
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Explore the profile of Clyde F Phelix including associated specialties, affiliations and a list of published articles.
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20
Citations
164
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Recent Articles
1.
Xu L, Phelix C, Chen L
J Chem Inf Model
. 2021 Oct;
61(11):5614-5625.
PMID: 34664967
Pyruvate metabolism requires the mitochondrial pyruvate carrier (MPC) proteins to transport pyruvate from the intermembrane space through the inner mitochondrial membrane to the mitochondrial matrix. The lack of the atomic...
2.
Chen L, Phelix C
Biochem Biophys Res Commun
. 2019 Mar;
511(3):573-578.
PMID: 30824189
The ubiquitous glucose transporter 1 (GLUT1) is physiologically and pathologically relevant in energy metabolism of the CNS, skeletal muscles, cancer cells etc. Extensive experiments on GLUT1 produced thorough understandings of...
3.
Wang C, Zhao F, Shen K, Wang W, Siedlak S, Lee H, et al.
Brain Pathol
. 2018 Dec;
29(4):530-543.
PMID: 30515907
Disturbed neuronal cholesterol homeostasis has been observed in Alzheimer disease (AD) and contributes to the pathogenesis of AD. As the master switch of cholesterol biosynthesis, the sterol regulatory element-binding protein...
4.
Liang H, Bourdon A, Chen L, Phelix C, Perry G
ACS Chem Neurosci
. 2018 Jun;
9(11):2815-2823.
PMID: 29865792
Fourteen glucose transporters (GLUTs) play essential roles in human physiology by facilitating glucose diffusion across the cell membrane. Due to its central role in the energy metabolism of the central...
5.
Phelix C, Bourdon A, Villareal G, LeBaron R
Annu Int Conf IEEE Eng Med Biol Soc
. 2017 Mar;
2016:1434-1438.
PMID: 28268595
There is need for modeling biological systems to accelerate drug pipelines for treating metabolic diseases. The eliglustat treatment for Gaucher disease is approved by the FDA with a companion genomic...
6.
Moritz R, LeBaron R, Phelix C, Rupaimoole R, Kim H, Tsin A, et al.
Int J Clin Med
. 2017 Feb;
7(7):496-510.
PMID: 28149671
Metabolically stressed kidney is in part characterized by infiltrating macrophages and macrophage-derived TGF-1 that promote the synthesis of various ECM molecules. TGF-1 strongly enhances the expression of the gene that...
7.
Phelix C, Villareal G, LeBaron R, Roberson D
Annu Int Conf IEEE Eng Med Biol Soc
. 2015 Jan;
2014:3452-5.
PMID: 25570733
We validated a model of the TGF-β signaling pathway using reactions from Reactome. Using a patentpending technique, gene expression profiles from individual patients are used to determine model parameters. Gene...
8.
Sandstrom R, Foret M, Grow D, Haugen E, Rhodes C, Cardona A, et al.
Sci Rep
. 2014 Jun;
4:5371.
PMID: 24947819
Histone 3 lysine 4 trimethylation (H3K4me3) is known to be associated with transcriptionally active or poised genes and required for postnatal neurogenesis within the subventricular zone (SVZ) in the rodent...
9.
Fujioka H, Phelix C, Friedland R, Zhu X, Perry E, Castellani R, et al.
J Health Care Poor Underserved
. 2013 Nov;
24(4 Suppl):70-8.
PMID: 24241262
Apolipoprotein E 4 (ApoE 4) has been linked to pathogenesis of Alzheimer's disease and has been suggested to be maintained through evolutionary pressure via a protective role in malaria infection....
10.
Young N, Szabo C, Phelix C, Flaherty D, Balaram P, Foust-Yeoman K, et al.
Proc Natl Acad Sci U S A
. 2013 Nov;
110(47):19107-12.
PMID: 24191031
Epilepsy is characterized by recurrent seizure activity that can induce pathological reorganization and alter normal function in neocortical networks. In the present study, we determined the numbers of cells and...