Lesley D OBrien
Overview
Explore the profile of Lesley D OBrien including associated specialties, affiliations and a list of published articles.
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4
Citations
41
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Recent Articles
1.
Dodu J, Moncayo R, Damaj M, Schlosburg J, Akbarali H, OBrien L, et al.
J Pharmacol Exp Ther
. 2021 Oct;
380(1):1-14.
PMID: 34625464
Opioid use disorder reflects a major public health crisis of morbidity and mortality in which opioid withdrawal often contributes to continued use. However, current medications that treat opioid withdrawal symptoms...
2.
OBrien L, Smith T, Donvito G, Cravatt B, Newton J, Spiegel S, et al.
Cannabis Cannabinoid Res
. 2021 Jun;
6(6):508-521.
PMID: 34142866
The endogenous cannabinoid system modulates inflammatory signaling in a variety of pathological states, including traumatic brain injury (TBI). The selective expression of diacylglycerol lipase-β (DAGL-β), the 2-arachidonylglycerol biosynthetic enzyme, on...
3.
OBrien L, Sticht M, Mitchnick K, Limebeer C, Parker L, Winters B
Neurosci Lett
. 2014 Jul;
578:192-6.
PMID: 25004406
Cannabinoid agonists typically impair memory, whereas CB1 receptor antagonists enhance memory performance under specific conditions. The insular cortex has been implicated in object memory consolidation. Here we show that infusions...
4.
OBrien L, Wills K, Segsworth B, Dashney B, Rock E, Limebeer C, et al.
Pharmacol Biochem Behav
. 2012 Oct;
103(3):597-602.
PMID: 23103902
The acute effects of cannabinoid compounds have been investigated in animal models of anxiety-like behavior and palatability processing. However, the chronic effects of cannabinoids in such models are poorly understood....