Les Henderson
Overview
Explore the profile of Les Henderson including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
686
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Recent Articles
1.
Cosper P, Paracha M, Jones K, Hrycyniak L, Henderson L, Bryan A, et al.
bioRxiv
. 2024 Sep;
PMID: 39345631
Statement Of Significance: Cancer cells and laryngeal tumors with higher chromosome missegregation rates are more sensitive to radiation therapy, supporting chromosomal instability as a promising biomarker of radiation response.
2.
Lynch A, Bradford S, Zhou A, Oxendine K, Henderson L, Horner V, et al.
Proc Natl Acad Sci U S A
. 2024 Apr;
121(16):e2309621121.
PMID: 38588415
Chromosomal instability (CIN) is the persistent reshuffling of cancer karyotypes via chromosome mis-segregation during cell division. In cancer, CIN exists at varying levels that have differential effects on tumor progression....
3.
Lynch A, Bradford S, Zhou A, Oxendine K, Henderson L, Horner V, et al.
bioRxiv
. 2023 Jul;
PMID: 37398147
Chromosomal instability (CIN) is the persistent reshuffling of cancer karyotypes via chromosome mis-segregation during cell division. In cancer, CIN exists at varying levels that have differential effects on tumor progression....
4.
Hiemenz M, Kaur J, Kuang Z, Huang R, Harries L, Metzger D, et al.
Genes Chromosomes Cancer
. 2023 Mar;
62(8):460-470.
PMID: 36862145
Gene fusions involving EWSR1 or FUS as the 5' partner have been reported in a diverse array of sarcomas. Here, we characterize the histopathology and genomics of six tumors harboring...
5.
Matson D, Accola M, Henderson L, Shao X, Frater-Rubsam L, Horner V, et al.
Int J Gynecol Pathol
. 2021 Aug;
41(4):378-388.
PMID: 34380970
The ability to distinguish endometrial serous carcinoma (SC) from high-grade endometrioid adenocarcinoma is of great importance given their differences in prognosis and management. In practice, this distinction typically relies upon...
6.
Wong G, Zhou J, Liu J, Wu Z, Xu X, Li T, et al.
Nat Med
. 2018 Aug;
24(10):1627.
PMID: 30093730
In the Supplementary Information originally published with this article, a lane was missing in the β-actin blot in Supplementary Fig. 2. The lane has been added. The error has been...
7.
Wong G, Zhou J, Liu J, Wu Z, Xu X, Li T, et al.
Nat Med
. 2018 May;
24(7):968-977.
PMID: 29808010
The role of KRAS, when activated through canonical mutations, has been well established in cancer. Here we explore a secondary means of KRAS activation in cancer: focal high-level amplification of...
8.
Catenacci D, Liao W, Zhao L, Whitcomb E, Henderson L, ODay E, et al.
Gastric Cancer
. 2015 Nov;
19(4):1066-1079.
PMID: 26581548
Background: Trastuzumab has shown a survival benefit in cases of Her2-positive gastroesophageal cancer (GEC). Immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) currently determine eligibility for trastuzumab-based therapy. However, these...
9.
Catenacci D, Junttila M, Karrison T, Bahary N, Horiba M, Nattam S, et al.
J Clin Oncol
. 2015 Nov;
33(36):4284-92.
PMID: 26527777
Purpose: Sonic hedgehog (SHH), an activating ligand of smoothened (SMO), is overexpressed in > 70% of pancreatic cancers (PCs). We investigated the impact of vismodegib, an SHH antagonist, plus gemcitabine...
10.
Catenacci D, Liao W, Thyparambil S, Henderson L, Xu P, Zhao L, et al.
PLoS One
. 2014 Jul;
9(7):e100586.
PMID: 24983965
Background: Overexpression of Met tyrosine kinase receptor is associated with poor prognosis. Overexpression, and particularly MET amplification, are predictive of response to Met-specific therapy in preclinical models. Immunohistochemistry (IHC) of...