Leroy B Townsend
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Explore the profile of Leroy B Townsend including associated specialties, affiliations and a list of published articles.
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43
Citations
596
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Recent Articles
1.
Dittmer A, Woskobojnik I, Adfeldt R, Drach J, Townsend L, Voigt S, et al.
Antiviral Res
. 2016 Nov;
137:102-107.
PMID: 27871886
Background: Benzimidazole D-ribonucleosides are potent and selective inhibitors of CMV infection that have been shown to target the viral terminase, the enzyme complex responsible for viral DNA cleavage into single...
2.
Gentry B, Phan Q, Hall E, Breitenbach J, Borysko K, Kamil J, et al.
Antimicrob Agents Chemother
. 2014 Oct;
59(1):226-32.
PMID: 25348532
Human cytomegalovirus (HCMV) infection can cause severe illnesses, including encephalopathy and mental retardation, in immunocompromised and immunologically immature patients. Current pharmacotherapies for treating systemic HCMV infections include ganciclovir, cidofovir, and...
3.
Prichard M, Frederick S, Daily S, Borysko K, Townsend L, Drach J, et al.
Antimicrob Agents Chemother
. 2011 Feb;
55(5):2442-5.
PMID: 21300829
Several benzimidazole nucleoside analogs, including 1H-β-D-ribofuranosyl-2-bromo-5,6-dichlorobenzimidazole (BDCRB) and 1H-β-L-ribofuranosyl-2-isopropylamino-5,6-dichlorobenzimidazole (maribavir [MBV]), inhibit the replication of human cytomegalovirus. Neither analog inhibited the related betaherpesvirus human herpesvirus 6 (HHV-6). Additional analogs of...
4.
Ptak R, Gentry B, Hartman T, Watson K, Osterling M, Buckheit Jr R, et al.
Antimicrob Agents Chemother
. 2010 Jan;
54(4):1512-9.
PMID: 20086149
Triciribine (TCN) is a tricyclic nucleoside that inhibits human immunodeficiency virus type 1 (HIV-1) replication by a unique mechanism not involving the inhibition of enzymes directly involved in viral replication....
5.
Hwang J, Schilf R, Drach J, Townsend L, Bogner E
Antimicrob Agents Chemother
. 2009 Sep;
53(12):5095-101.
PMID: 19786605
Recently we characterized two inhibitors targeting the human cytomegalovirus (HCMV) terminase, 2-bromo-4,5,6-trichloro-1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl) benzimidazole (BTCRB) and 2,4,5,6-tetrachloro-1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl) benzimidazole (Cl(4)RB). The terminase consists of the ATP-hydrolyzing subunit pUL56 and the subunit pUL89...
6.
Hayashi K, Kamio S, Oono Y, Townsend L, Nozaki H
Phytochemistry
. 2009 Jan;
70(2):190-7.
PMID: 19171357
The auxins, plant hormones, play a crucial role in many aspects of plant development by regulating cell division, elongation and differentiation. Toyocamycin, a nucleoside-type antibiotic, was identified as auxin signaling...
7.
Chien T, Drach J, Townsend L
Nucleic Acids Symp Ser (Oxf)
. 2008 Sep;
(52):593-4.
PMID: 18776519
5-Alkylaminopyrazole nucleosides underwent nitrosation to give the corresponding N1-ribosylated 5-alkyl-amino-4-nitrosopyrazoles. The intramolecular cyclo-dehydration reactions of these 5-alkylamino-4-nitrosopyrazoles were carried out in pyridine at reflux temperature to afford the ring-closure N-1...
8.
Hwang J, Kregler O, Schilf R, Bannert N, Drach J, Townsend L, et al.
J Virol
. 2007 Aug;
81(21):11604-11.
PMID: 17728228
DNA packaging is the key step in viral maturation and involves binding and cleavage of viral DNA containing specific DNA-packaging motifs. This process is mediated by a group of specific...
9.
Lorenzi P, Landowski C, Brancale A, Song X, Townsend L, Drach J, et al.
Drug Metab Dispos
. 2006 Mar;
34(6):1070-7.
PMID: 16565170
The rapid in vivo degradation of the potent human cytomegalovirus inhibitor 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole (BDCRB) compared with a structural L-analog, maribavir (5,6-dichloro-2-(isopropylamino)-1-beta-L-ribofuranosyl-1H-benzimidazole), has been attributed to selective glycosidic bond cleavage. An enzyme...
10.
Chien T, Berry D, Drach J, Townsend L
Nucleosides Nucleotides Nucleic Acids
. 2006 Jan;
24(10-12):1971-96.
PMID: 16438060
3-Amino-6-(beta-D-ribofuranosyl)imidazo[4,5-c]pyrazole (2) was synthesized via an N-N bond formation strategy by a mononuclear heterocyclic rearrangement (MHR). A series of 5-amino-1-(5-O-tert-butyldimethylsilysilyl-2,3-O-isopropylidene-beta-D-ribofuranosyl)-4-(1,2,4-oxadiazol-3-yl)imidazoles (6a-d), with different substituents at the 5-position of the 1,2,4-oxadiazole,...