Leonid E Fridlyand
Overview
Explore the profile of Leonid E Fridlyand including associated specialties, affiliations and a list of published articles.
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15
Citations
367
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Recent Articles
1.
Fridlyand L, Tamarina N, Schally A, Philipson L
Front Endocrinol (Lausanne)
. 2016 Oct;
7:129.
PMID: 27777568
Growth hormone-releasing hormone (GHRH) is produced by the hypothalamus and stimulates growth hormone synthesis and release in the anterior pituitary gland. In addition, GHRH is an important regulator of cellular...
2.
Fridlyand L, Philipson L
PLoS One
. 2016 May;
11(5):e0152869.
PMID: 27138453
Insulin secretory in pancreatic beta-cells responses to nutrient stimuli and hormonal modulators include multiple messengers and signaling pathways with complex interdependencies. Here we present a computational model that incorporates recent...
3.
Fridlyand L, Jacobson D, Philipson L
Islets
. 2013 Apr;
5(1):1-15.
PMID: 23624892
In mammals an increase in glucose leads to block of ATP dependent potassium channels in pancreatic β cells leading to membrane depolarization. This leads to the repetitive firing of action...
4.
Fridlyand L, Philipson L
Islets
. 2012 Oct;
4(4):262-83.
PMID: 23093806
Glucagon, a peptide hormone secreted from the α-cells of the pancreatic islets, is critical for blood glucose homeostasis. We reviewed the literature and employed a computational systems analysis of intracellular...
5.
Fridlyand L, Philipson L
Prog Biophys Mol Biol
. 2011 Sep;
107(2):293-303.
PMID: 21920379
Insulin secretory responses to nutrient stimuli and hormonal modulators in pancreatic beta-cells are controlled by a variety of secondary messengers. We have analyzed numerous mechanisms responsible for regulated exocytosis in...
6.
Fridlyand L, Phillipson L
Islets
. 2011 Aug;
3(5):224-30.
PMID: 21814042
Pancreatic β-cells respond to rising blood glucose by increasing oxidative metabolism, leading to an increased ATP/ADP ratio in the cytoplasm with a subsequent influx of calcium and the eventual secretion...
7.
Fridlyand L, Philipson L
Theor Biol Med Model
. 2010 May;
7:15.
PMID: 20497556
Background: Pancreatic beta-cells respond to rising blood glucose by increasing oxidative metabolism, leading to an increased ATP/ADP ratio in the cytoplasm. This leads to a closure of KATP channels, depolarization...
8.
Fridlyand L, Philipson L
Curr Diabetes Rev
. 2008 Jan;
2(2):241-59.
PMID: 18220630
Insulin resistance (IRe) and a failure of insulin secretion are the major features of the early pathophysiology of type-2 diabetes mellitus (T2D) but the etiology is still not well understood....
9.
Fridlyand L, Harbeck M, Roe M, Philipson L
Am J Physiol Cell Physiol
. 2007 Oct;
293(6):C1924-33.
PMID: 17928534
In this report we describe a mathematical model for the regulation of cAMP dynamics in pancreatic beta-cells. Incretin hormones such as glucagon-like peptide 1 (GLP-1) increase cAMP and augment insulin...
10.
Fridlyand L, Philipson L
Med Hypotheses
. 2006 Jun;
67(5):1034-41.
PMID: 16797871
Unlabelled: Type 2 diabetes mellitus (T2D) is approaching epidemic proportions globally. However, some human populations, such as Western-Europeans, have a lower prevalence compared with urban or westernized groups with origins...