Leone Beagley
Overview
Explore the profile of Leone Beagley including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
657
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0
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Recent Articles
11.
Holmes-Liew C, Holmes M, Beagley L, Hopkins P, Chambers D, Smith C, et al.
Clin Transl Immunology
. 2015 Apr;
4(3):e35.
PMID: 25859390
Infections with cytomegalovirus (CMV) can induce severe complications after solid organ transplantation (SOT). The prognosis for ganciclovir-resistant CMV infection and disease is particularly poor. Whereas adoptive transfer of CMV-specific T...
12.
Smith C, Okern G, Rehan S, Beagley L, Lee S, Aarvak T, et al.
Clin Transl Immunology
. 2015 Feb;
4(1):e31.
PMID: 25671129
The manufacture of clinical grade cellular products for adoptive immunotherapy requires ex vivo culture and expansion of human T cells. One of the key components in manufacturing of T cell...
13.
Schuessler A, Smith C, Beagley L, Boyle G, Rehan S, Matthews K, et al.
Cancer Res
. 2014 May;
74(13):3466-76.
PMID: 24795429
Glioblastoma multiforme (GBM) is one of the most aggressive human brain malignancies. Even with optimal treatment, median survival is less than 6 months for patients with recurrent GBM. Immune-based therapies...
14.
Pender M, Csurhes P, Smith C, Beagley L, Hooper K, Raj M, et al.
Mult Scler
. 2014 Feb;
20(11):1541-4.
PMID: 24493474
Defective control of Epstein-Barr virus (EBV) infection by cytotoxic CD8(+) T cells might predispose to multiple sclerosis (MS) by allowing EBV-infected autoreactive B cells to accumulate in the central nervous...
15.
Crough T, Beagley L, Smith C, Jones L, Walker D, Khanna R
Immunol Cell Biol
. 2012 Apr;
90(9):872-80.
PMID: 22508289
The frequent detection of human cytomegalovirus (CMV) antigens in glioblastoma multiforme (GBM) has raised the possibility of exploiting CMV-specific T-cell immunotherapy to control this disease in CMV--seropositive patients. Here, we...
16.
Smith C, Tsang J, Beagley L, Chua D, Lee V, Li V, et al.
Cancer Res
. 2012 Jan;
72(5):1116-25.
PMID: 22282657
Nasopharyngeal carcinoma (NPC) is endemic in China and Southeast Asia where it is tightly associated with infections by Epstein-Barr virus (EBV). The role of tumor-associated viral antigens in NPC renders...
17.
Smith C, Wakisaka N, Crough T, Peet J, Yoshizaki T, Beagley L, et al.
Blood
. 2009 Apr;
113(24):6148-52.
PMID: 19372256
Activation of the nuclear factor-kappaB pathway by Epstein-Barr virus-encoded latent membrane protein-1 (LMP-1) leads to an up-regulation of the major histocompatibility complex class I antigen-processing pathway. Paradoxically, LMP-1 itself induces...
18.
Smith C, Beagley L, Khanna R
J Virol
. 2009 Apr;
83(12):6192-8.
PMID: 19357166
Latent membrane antigen 1 and -2 (LMP-1/2)-specific CD8(+) T cells from newly diagnosed and relapsed Hodgkin's lymphoma (HL) patients display a selective functional impairment. In contrast, CD8(+) T cells specific...
19.
Shafren D, Au G, Nguyen T, Newcombe N, Haley E, Beagley L, et al.
Clin Cancer Res
. 2004 Jan;
10(1 Pt 1):53-60.
PMID: 14734451
Purpose: The incidence of malignant melanoma continues to increase worldwide; however, treatment of metastatic melanoma remains unsatisfactory, and there is an urgent need for development of effective targeted therapeutics. A...