Leonardo G Ferreira
Overview
Explore the profile of Leonardo G Ferreira including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
684
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Recent Articles
1.
Dos Santos R, Ferreira L, Andricopulo A
Methods Mol Biol
. 2018 Mar;
1762:31-50.
PMID: 29594766
Drug discovery has evolved significantly over the past two decades. Progress in key areas such as molecular and structural biology has contributed to the elucidation of the three-dimensional structure and...
2.
Ferreira L, Oliva G, Andricopulo A
An Acad Bras Cienc
. 2018 Feb;
90(1 Suppl 1):645-661.
PMID: 29451603
Scientific and technological breakthroughs have compelled the current players in drug discovery to increasingly incorporate knowledge-based approaches. This evolving paradigm, which has its roots attached to the recent advances in...
3.
Ferreira L, Andricopulo A
Pharmacol Ther
. 2017 Jun;
180:49-61.
PMID: 28579388
Chagas disease and human African trypanosomiasis are endemic conditions in Latin America and Africa, respectively, for which no effective and safe therapy is available. Efforts in drug discovery have focused...
4.
Pauli I, Ferreira L, de Souza M, Oliva G, Ferreira R, Dessoy M, et al.
Future Med Chem
. 2017 May;
9(7):641-657.
PMID: 28509592
Aim: Chagas disease is endemic in Latin America and no effective treatment is available. Efforts in drug research have focused on several enzymes from Trypanosoma cruzi, among which cruzain is...
5.
Ferreira L, Andricopulo A
Curr Top Med Chem
. 2017 Feb;
17(20):2260-2270.
PMID: 28240184
Fragment-based drug discovery (FBDD) is a broadly used strategy in structure-guided ligand design, whereby low-molecular weight hits move from lead-like to drug-like compounds. Over the past 15 years, an increasingly...
6.
Mafud A, Ferreira L, Mascarenhas Y, Andricopulo A, de Moraes J
Trends Parasitol
. 2016 Sep;
32(11):874-886.
PMID: 27593339
Schistosomiasis, a chronic neglected tropical disease caused by Schistosoma worms, is reported in nearly 80 countries. Although the disease affects approximately 260 million people, the treatment relies exclusively on praziquantel,...
7.
Ferreira L, Oliva G, Andricopulo A
Expert Opin Drug Discov
. 2016 Aug;
11(10):957-68.
PMID: 27554357
Introduction: Pocket-based drug design has contributed to major scientific breakthroughs in pharmaceutical research and development (R&D). The integrated use of experimental and computational methods, primarily during the early phases of...
8.
Ferreira L, Andricopulo A
Drug Discov Today
. 2016 Jul;
21(10):1699-1710.
PMID: 27365271
Identifying new indications for clinically useful drugs is a worthwhile approach for neglected tropical diseases. The number of successful repurposing cases in the field is growing as not-for-profit organizations, in...
9.
Ferreira L, de Oliveira M, Andricopulo A
Curr Top Med Chem
. 2016 Apr;
16(20):2290-302.
PMID: 27072717
Chagas disease represents a serious burden for millions of people worldwide. Transmitted by the protozoan parasite Trypanosoma cruzi, this neglected tropical disease causes more than 10,000 deaths each year and...
10.
Ferreira L, Dos Santos R, Oliva G, Andricopulo A
Molecules
. 2015 Jul;
20(7):13384-421.
PMID: 26205061
Pharmaceutical research has successfully incorporated a wealth of molecular modeling methods, within a variety of drug discovery programs, to study complex biological and chemical systems. The integration of computational and...