Leonardo A Moraes
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Explore the profile of Leonardo A Moraes including associated specialties, affiliations and a list of published articles.
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24
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688
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Recent Articles
11.
Vaiyapuri S, Ali M, Moraes L, Sage T, Lewis K, Jones C, et al.
Arterioscler Thromb Vasc Biol
. 2013 Oct;
33(12):2740-9.
PMID: 24135020
Objective: Dietary flavonoids have long been appreciated in reducing cardiovascular disease risk factors, but their mechanisms of action are complex in nature. In this study, the effects of tangeretin, a...
12.
Vaiyapuri S, Moraes L, Sage T, Ali M, Lewis K, Mahaut-Smith M, et al.
Nat Commun
. 2013 Oct;
4:2564.
PMID: 24096827
The presence of multiple connexins was recently demonstrated in platelets, with notable expression of Cx37. Studies with Cx37-deficient mice and connexin inhibitors established roles for hemichannels and gap junctions in...
13.
Moraes L, Vaiyapuri S, Sasikumar P, Ali M, Kriek N, Sage T, et al.
Blood
. 2013 Sep;
122(18):3188-96.
PMID: 24030383
Statins are widely prescribed cholesterol-lowering drugs that are a first-line treatment of coronary artery disease and atherosclerosis, reducing the incidence of thrombotic events such as myocardial infarction and stroke. Statins...
14.
Vaiyapuri S, Jones C, Sasikumar P, Moraes L, Munger S, Wright J, et al.
Circulation
. 2012 Apr;
125(20):2479-91.
PMID: 22528526
Background: Connexins are a widespread family of membrane proteins that assemble into hexameric hemichannels, also known as connexons. Connexons regulate membrane permeability in individual cells or couple between adjacent cells...
15.
Jones C, Barrett N, Moraes L, Gibbins J, Jackson D
Methods Mol Biol
. 2011 Dec;
788:341-66.
PMID: 22130718
The response of platelets to changes in the immediate environment is always a balance between activatory and inhibitory signals, the cumulative effect of which is either activation or quiescence. This...
16.
Jones C, Moraes L, Gibbins J
Platelets
. 2011 Nov;
23(5):331-5.
PMID: 22035359
Platelet endothelial cell adhesion molecule-1 (PECAM-1), an immunoreceptor tyrosine-based inhibitory motif containing receptor, plays diverse and apparently contradictory roles in regulating the response of platelets to stimuli; inhibiting platelet response...
17.
Spyridon M, Moraes L, Jones C, Sage T, Sasikumar P, Bucci G, et al.
Blood
. 2011 Mar;
117(21):5751-61.
PMID: 21411760
Liver X receptors (LXRs) are transcription factors involved in the regulation of cholesterol homeostasis. LXR ligands have athero-protective properties independent of their effects on cholesterol metabolism. Platelets are involved in...
18.
Wright B, Moraes L, Kemp C, Mullen W, Crozier A, Lovegrove J, et al.
Br J Pharmacol
. 2010 Feb;
159(6):1312-25.
PMID: 20148891
Background And Purpose: Molecular mechanisms underlying the links between dietary intake of flavonoids and reduced cardiovascular disease risk are only partially understood. Key events in the pathogenesis of cardiovascular disease,...
19.
Jones C, Garner S, Moraes L, Kaiser W, Rankin A, Ouwehand W, et al.
FEBS Lett
. 2009 Oct;
583(22):3618-24.
PMID: 19850043
Platelet endothelial cell adhesion molecule-1 (PECAM-1) inhibits platelet response to collagen and may also inhibit two other major platelet agonists ADP and thrombin although this has been less well explored....
20.
Nongenomic signaling of the retinoid X receptor through binding and inhibiting Gq in human platelets
Moraes L, Swales K, Wray J, Damazo A, Gibbins J, Warner T, et al.
Blood
. 2007 Jan;
109(9):3741-4.
PMID: 17213293
Retinoid X receptors (RXRs) are important transcriptional nuclear hormone receptors, acting as either homodimers or the binding partner for at least one fourth of all the known human nuclear receptors....