Leonardo A Moraes
Overview
Explore the profile of Leonardo A Moraes including associated specialties, affiliations and a list of published articles.
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24
Citations
688
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Recent Articles
1.
Zharkova O, Salamah M, Babak M, Rajan E, Lim L, Andrade F, et al.
Int J Mol Sci
. 2023 Feb;
24(4).
PMID: 36834844
Annexin A1 (ANXA1) is an endogenous protein, which plays a central function in the modulation of inflammation. While the functions of ANXA1 and its exogenous peptidomimetics, -Acetyl 2-26 ANXA1-derived peptide...
2.
Salamah M, Ravishankar D, Vaiyapuri R, Moraes L, Patel K, Perretti M, et al.
J Thromb Haemost
. 2019 Apr;
17(7):1120-1133.
PMID: 31033193
Background: Formyl peptide receptors (FPRs) play pivotal roles in the regulation of innate immunity and host defense. The FPRs include three family members: FPR1, FPR2/ALX, and FPR3. The activation of...
3.
Salamah M, Ravishankar D, Kodji X, Moraes L, Williams H, Vallance T, et al.
Blood Adv
. 2018 Nov;
2(21):2973-2985.
PMID: 30413433
Platelet-associated complications including thrombosis, thrombocytopenia, and hemorrhage are commonly observed during various inflammatory diseases such as sepsis, inflammatory bowel disease, and psoriasis. Despite the reported evidence on numerous mechanisms/molecules that...
4.
Moraes L, Ampomah P, Lim L
Cell Adh Migr
. 2018 Aug;
12(5):417-423.
PMID: 30122097
Targeting inflammation in cancer has shown promise to improve and complement current therapies. The tumor microenvironment plays an important role in cancer growth and metastasis and -tumor associated macrophages possess...
5.
Moraes L, Kar S, Foo S, Gu T, Toh Y, Ampomah P, et al.
Sci Rep
. 2017 Dec;
7(1):17925.
PMID: 29263330
Macrophages are potent immune cells with well-established roles in the response to stress, injury, infection and inflammation. The classically activated macrophages (M1) are induced by lipopolysaccharide (LPS) and express a...
6.
Ampomah P, Moraes L, Lukman H, Lim L
FASEB J
. 2017 Nov;
32(3):1468-1478.
PMID: 29127186
The regulation of host factors is a key strategy employed by viruses to suppress host defense systems and enhance their propagation; however, the mechanisms that underlie this regulation is still...
7.
Moraes L, Unsworth A, Vaiyapuri S, Ali M, Sasikumar P, Sage T, et al.
Arterioscler Thromb Vasc Biol
. 2016 Oct;
36(12):2324-2333.
PMID: 27758768
Objective: Although initially seemingly paradoxical because of the lack of nucleus, platelets possess many transcription factors that regulate their function through DNA-independent mechanisms. These include the farnesoid X receptor (FXR),...
8.
Vaiyapuri S, Roweth H, Ali M, Unsworth A, Stainer A, Flora G, et al.
Br J Pharmacol
. 2015 May;
172(16):4133-45.
PMID: 25988959
Background And Purpose: The discovery that flavonoids are capable of inhibiting platelet function has led to their investigation as potential antithrombotic agents. However, despite the range of studies on the...
9.
Vaiyapuri S, Sage T, Rana R, Schenk M, Ali M, Unsworth A, et al.
Blood
. 2014 Nov;
125(4):720-30.
PMID: 25370417
The Eph kinases, EphA4 and EphB1, and their ligand, ephrinB1, have been previously reported to be present in platelets where they contribute to thrombus stability. Although thrombus formation allows for...
10.
Jones C, Sage T, Moraes L, Vaiyapuri S, Hussain U, Tucker K, et al.
Arterioscler Thromb Vasc Biol
. 2014 Jun;
34(9):1968-76.
PMID: 24969778
Objective: Platelet endothelial cell adhesion molecule-1 (PECAM-1) regulates platelet response to multiple agonists. How this immunoreceptor tyrosine-based inhibitory motif-containing receptor inhibits G protein-coupled receptor-mediated thrombin-induced activation of platelets is unknown....