Leonard R Johnson
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Explore the profile of Leonard R Johnson including associated specialties, affiliations and a list of published articles.
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48
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1008
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Recent Articles
1.
Tigyi G, Johnson L, Lee S, Norman D, Szabo E, Balogh A, et al.
J Lipid Res
. 2019 Jan;
60(3):464-474.
PMID: 30692142
The growth factor-like lipid mediator, lysophosphatidic acid (LPA), is a potent signaling molecule that influences numerous physiologic and pathologic processes. Manipulation of LPA signaling is of growing pharmacotherapeutic interest, especially...
2.
Thompson K, Ray R, Alli S, Ge W, Boler A, McCool W, et al.
Exp Biol Med (Maywood)
. 2018 Sep;
243(13):1056-1065.
PMID: 30253666
A critical barrier in treating diarrheal disease is easy-to-use effective treatments. Rx100 is a first in class, novel small molecule that has shown efficacy after both subcutaneous and oral administration...
3.
Ray R, Bavaria M, Johnson L
Cell Signal
. 2015 Jun;
27(9):1850-9.
PMID: 26093026
Tissue polyamine levels are largely determined by the activity of ornithine decarboxylase (ODC, EC 4.1.17), which catalyzes the conversion of ornithine to the diamine putrescine. The activity of the enzyme...
4.
Deng W, Kimura Y, Gududuru V, Wu W, Balogh A, Szabo E, et al.
Radiat Res
. 2015 Mar;
183(4):465-75.
PMID: 25807318
We have previously demonstrated that the small molecule octadecenyl thiophosphate (OTP), a synthetic mimic of the growth factor-like mediator lysophosphatidic acid (LPA), showed radioprotective activity in a mouse model of...
5.
Ray R, Bhattacharya S, Bavaria M, Viar M, Johnson L
Amino Acids
. 2014 Jun;
46(9):2231-9.
PMID: 24930035
Since antizyme (AZ) is known to inhibit cell proliferation and to increase apoptosis, the question arises as to whether these effects occur independently of polyamines. Intestinal epithelial cells (IEC-6) were...
6.
Ray R, Bhattacharya S, Bavaria M, Viar M, Johnson L
Amino Acids
. 2014 May;
46(8):2005-13.
PMID: 24824458
Although intracellular polyamine levels are highly regulated, it is unclear whether intracellular putrescine (PUT), spermidine (SPD), or spermine (SPM) levels act as a sensor to regulate their synthesis or uptake....
7.
Bavaria M, Jin S, Ray R, Johnson L
Apoptosis
. 2013 Nov;
19(3):467-79.
PMID: 24253595
Polyamine-depletion inhibited apoptosis by activating ERK1/2, while, preventing JNK1/2 activation. MKP-1 knockdown by SiRNA increased ERK1/2, JNK1/2, and p38 phosphorylation and apoptosis. Therefore, we predicted that polyamines might regulate MKP1...
8.
Bhattacharya S, Ray R, Johnson L
Apoptosis
. 2013 Nov;
19(3):451-66.
PMID: 24242917
Homeostasis of the gastrointestinal epithelium is dependent upon a balance between cell proliferation and apoptosis. Cyclin-dependent kinases (Cdks) are well known for their role in cell proliferation. Previous studies from...
9.
Ray R, Johnson L
Amino Acids
. 2013 Aug;
46(3):565-73.
PMID: 23904095
Amino acids, especially glutamine (GLN) have been known for many years to stimulate the growth of small intestinal mucosa. Polyamines are also required for optimal mucosal growth, and the inhibition...
10.
Bhattacharya S, Chaum E, Johnson D, Johnson L
Invest Ophthalmol Vis Sci
. 2012 Nov;
53(13):8350-66.
PMID: 23139272
Purpose: Relatively little is known about the contribution of p53/Mdm2 pathway in apoptosis of retinal pigment epithelial (RPE) cells or its possible link to dysfunction of aging RPE or to...