Leonard D Spicer
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Explore the profile of Leonard D Spicer including associated specialties, affiliations and a list of published articles.
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12
Citations
160
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Recent Articles
1.
Gobeil S, Bobay B, Juvvadi P, Cole D, Heitman J, Steinbach W, et al.
mBio
. 2021 Nov;
12(6):e0300021.
PMID: 34809463
Calcineurin is a critical enzyme in fungal pathogenesis and antifungal drug tolerance and, therefore, an attractive antifungal target. Current clinically accessible calcineurin inhibitors, such as FK506, are immunosuppressive to humans,...
2.
Dahora L, Verheul M, Williams K, Jin C, Stockdale L, Cavet G, et al.
Sci Immunol
. 2021 Oct;
6(64):eabj1181.
PMID: 34714686
Vaccine development to prevent Typhi infections has accelerated over the past decade, resulting in licensure of new vaccines, which use the Vi polysaccharide (Vi PS) of the bacterium conjugated to...
3.
Juvvadi P, Bobay B, Gobeil S, Cole D, Venters R, Heitman J, et al.
Biochem Biophys Res Commun
. 2020 Mar;
526(1):48-54.
PMID: 32192767
The 12-kDa FK506-binding protein (FKBP12) is the target of the commonly used immunosuppressive drug FK506. The FKBP12-FK506 complex binds to calcineurin and inhibits its activity, leading to immunosuppression and preventing...
4.
Juvvadi P, Fox 3rd D, Bobay B, Hoy M, Gobeil S, Venters R, et al.
Nat Commun
. 2019 Sep;
10(1):4275.
PMID: 31537789
Calcineurin is important for fungal virulence and a potential antifungal target, but compounds targeting calcineurin, such as FK506, are immunosuppressive. Here we report the crystal structures of calcineurin catalytic (CnA)...
5.
Gobeil S, Bobay B, Spicer L, Venters R
Biomol NMR Assign
. 2019 Feb;
13(1):207-212.
PMID: 30707421
Invasive fungal infections are a leading cause of death in immunocompromised patients and remain difficult to treat since fungal pathogens, like mammals, are eukaryotes and share many orthologous proteins. As...
6.
Reardon P, Sage H, Dennison S, Martin J, Donald B, Alam S, et al.
Proc Natl Acad Sci U S A
. 2014 Jan;
111(4):1391-6.
PMID: 24474763
The membrane proximal external region (MPER) of HIV-1 glycoprotein (gp) 41 is involved in viral-host cell membrane fusion. It contains short amino acid sequences that are binding sites for the...
7.
Robinson K, Reardon P, Spicer L
Methods Mol Biol
. 2011 Dec;
831:261-77.
PMID: 22167679
A living cell is a complex system that contains many biological macromolecules and small molecules necessary for survival, in a relatively small volume. It is within this crowded and complex...
8.
Augustus A, Spicer L
BMC Genomics
. 2011 Nov;
12:558.
PMID: 22082356
Background: Whole-genome sequencing of bacteria has proceeded at an exponential pace but annotation validation has lagged behind. For instance, the MetJ regulon, which controls methionine biosynthesis and transport, has been...
9.
Augustus A, Sage H, Spicer L
Biochemistry
. 2010 Mar;
49(15):3289-95.
PMID: 20196619
We have used analytical ultracentrifugation to characterize the binding of the methionine repressor protein, MetJ, to synthetic oligonucleotides containing zero to five specific recognition sites, called metboxes. For all lengths...
10.
Augustus A, Reardon P, Spicer L
Proc Natl Acad Sci U S A
. 2009 Mar;
106(13):5065-9.
PMID: 19289840
Atomic level characterization of proteins and other macromolecules in the living cell is challenging. Recent advances in NMR instrumentation and methods, however, have enabled in-cell studies with prospects for multidimensional...