William J Steinbach
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Explore the profile of William J Steinbach including associated specialties, affiliations and a list of published articles.
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164
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7520
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Recent Articles
1.
Dome P, Jeong P, Nam G, Jang H, Rivera A, Floyd Averette A, et al.
Proc Natl Acad Sci U S A
. 2024 Dec;
122(1):e2419883121.
PMID: 39739817
Invasive fungal infections are a leading cause of death worldwide. Translating molecular insights into clinical benefits is challenging because fungal pathogens and their hosts share similar eukaryotic physiology. Consequently, current...
2.
Bucayu R, Boge C, Yildirim I, Aviles-Robles M, Vora S, Berman D, et al.
J Pediatric Infect Dis Soc
. 2024 Nov;
13(12):633-638.
PMID: 39513400
Of 319 children with invasive candidiasis, 67 (21%) transitioned from intravenous to enteral antifungal therapy. Eight (12%) transitioned back to intravenous antifungal therapy, one due to perceived treatment failure defined...
3.
Dome P, Jeong P, Nam G, Jang H, Rivera A, Floyd Averette A, et al.
bioRxiv
. 2024 Oct;
PMID: 39386510
Significance: Invasive fungal infections cause significant mortality worldwide, and current antifungal treatments are often ineffective, toxic, or face growing resistance. This research identifies calcineurin (CaN), a critical protein for fungal...
4.
Oliva-Hemker M, Kahn S, Steinbach W
Pediatrics
. 2023 Nov;
152(6).
PMID: 37981872
Fecal microbiota transplantation (FMT) involves the delivery of an entire microbial community from a healthy donor to a recipient with the intention of ameliorating or curing a specific disease. Current...
5.
Maji A, Soutar C, Zhang J, Lewandowska A, Uno B, Yan S, et al.
Nature
. 2023 Nov;
623(7989):1079-1085.
PMID: 37938782
Decades of previous efforts to develop renal-sparing polyene antifungals were misguided by the classic membrane permeabilization model. Recently, the clinically vital but also highly renal-toxic small-molecule natural product amphotericin B...
6.
Rivera A, Lim W, Park E, Dome P, Hoy M, Spasojevic I, et al.
mBio
. 2023 Sep;
14(5):e0181023.
PMID: 37737622
Fungal infections cause significant morbidity and mortality globally. The therapeutic armamentarium against these infections is limited, and the development of antifungal drugs has been hindered by the evolutionary conservation between...
7.
Wattier R, Bucayu R, Boge C, Ross R, Yildirim I, Zaoutis T, et al.
J Pediatric Infect Dis Soc
. 2023 Aug;
12(9):487-495.
PMID: 37589394
Background: Adjunctive diagnostic studies (aDS) are recommended to identify occult dissemination in patients with candidemia. Patterns of evaluation with aDS across pediatric settings are unknown. Methods: Candidemia episodes were included...
8.
Rivera A, Lim W, Park E, Dome P, Hoy M, Spasojevic I, et al.
bioRxiv
. 2023 Jun;
PMID: 37333270
Importance: Fungal infections cause significant morbidity and mortality globally. The therapeutic armamentarium against these infections is limited and development of antifungal drugs has been hindered by the evolutionary conservation between...
9.
Neofytos D, Steinbach W, Hanson K, Carpenter P, Papanicolaou G, Slavin M
Transplant Cell Ther
. 2023 Jan;
29(4):222-227.
PMID: 36649748
The Practice Guidelines Committee of the American Society of Transplantation and Cellular Therapy (ASTCT) partnered with its Transplant Infectious Disease Special Interest Group (TID-SIG) to update its 2009 compendium-style infectious...
10.
Juvvadi P, Bobay B, Cole D, Awwa M, Steinbach W
J Fungi (Basel)
. 2022 Dec;
8(12).
PMID: 36547614
Calcineurin (CN) is an attractive antifungal target as it is critical for growth, stress response, drug resistance, and virulence in fungal pathogens. The immunosuppressive drugs, tacrolimus (FK506) and cyclosporin A...