Lenka Bittova
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Explore the profile of Lenka Bittova including associated specialties, affiliations and a list of published articles.
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14
Citations
459
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0
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Recent Articles
1.
Sedlak D, Tuma R, Kolla J, Mokhamatam R, Bahrova L, Lisova M, et al.
J Mol Biol
. 2024 Nov;
437(2):168883.
PMID: 39608634
Transcription factors of the bHLH-PAS family play vital roles in animal development, physiology, and disease. Two members of the family require binding of low-molecular weight ligands for their activity: the...
2.
Jindra M, Tumova S, Bittova L, Tuma R, Sedlak D
Curr Opin Insect Sci
. 2024 Jul;
65:101234.
PMID: 39025365
Juvenile hormone (JH) signaling is realized at the gene regulatory level by receptors of the bHLH-PAS transcription factor family. The sesquiterpenoid hormones and their synthetic mimics are agonist ligands of...
3.
Tumova S, Milacek M, Snajdr I, Muthu M, Tuma R, reha D, et al.
Proc Natl Acad Sci U S A
. 2022 Nov;
119(48):e2215541119.
PMID: 36409882
Juvenile hormones (JHs) control insect metamorphosis and reproduction. JHs act through a receptor complex consisting of methoprene-tolerant (Met) and taiman (Tai) proteins to induce transcription of specific genes. Among chemically...
4.
Jindra M, McKinstry W, Nebl T, Bittova L, Ren B, Shaw J, et al.
J Biol Chem
. 2021 Nov;
297(6):101387.
PMID: 34758356
Juvenile hormone (JH) plays vital roles in insect reproduction, development, and in many aspects of physiology. JH primarily acts at the gene-regulatory level through interaction with an intracellular receptor (JH...
5.
Milacek M, Bittova L, Tumova S, Luksan O, Hanus R, Kyjakova P, et al.
Insect Biochem Mol Biol
. 2021 Oct;
139:103671.
PMID: 34656795
Juvenile hormone (JH) controls insect reproduction and development through an intracellular receptor complex comprising two bHLH-PAS proteins, the JH-binding Methoprene-tolerant (Met) and its partner Taiman (Tai). Many hemimetabolous insects including...
6.
Jindra M, Bittova L
Arch Insect Biochem Physiol
. 2019 Sep;
103(3):e21615.
PMID: 31502704
Synthetic compounds that mimic the action of juvenile hormones (JHs) are founding members of a class of insecticides called insect growth regulators (IGRs). Like JHs, these juvenoids block metamorphosis of...
7.
Bittova L, Jedlicka P, Dracinsky M, Kirubakaran P, Vondrasek J, Hanus R, et al.
J Biol Chem
. 2018 Nov;
294(2):410-423.
PMID: 30455350
The sesquiterpenoid juvenile hormone (JH) is vital to insect development and reproduction. Intracellular JH receptors have recently been established as basic helix-loop-helix transcription factor (bHLH)/PAS proteins in known as germ...
8.
Muller M, Fierz B, Bittova L, Liszczak G, Muir T
Nat Chem Biol
. 2016 Jan;
12(3):188-93.
PMID: 26807716
Specialized chromatin domains contribute to nuclear organization and regulation of gene expression. Gene-poor regions are di- and trimethylated at lysine 9 of histone H3 (H3K9me2 and H3K9me3) by the histone...
9.
Nguyen U, Bittova L, Muller M, Fierz B, David Y, Houck-Loomis B, et al.
Nat Methods
. 2014 Jul;
11(8):834-40.
PMID: 24997861
Elucidating the molecular details of how chromatin-associated factors deposit, remove and recognize histone post-translational modification (PTM) signatures remains a daunting task in the epigenetics field. We introduce a versatile platform...
10.
Bitto E, Bingman C, Bittova L, Frederick R, Fox B, Phillips Jr G
Proteins
. 2009 Feb;
76(2):477-83.
PMID: 19241471
Many essential physiological processes are regulated by the modulation of calcium concentration in the cell. The EF-hand proteins represent a superfamily of calcium-binding proteins involved in calcium signaling and homeostasis....