David Sedlak
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Explore the profile of David Sedlak including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Novackova K, Droz L, Korinek M, Sedlak D, Bartunek P, Eigner V, et al.
Comb Chem High Throughput Screen
. 2025 Jan;
PMID: 39806971
Objective: In search of efficient anticancer agents, we aimed at the design and synthesis of a library of tetrasubstituted alkenes. These are structural analogues of tamoxifen, one of the widely...
2.
Nikulenkov F, Carbain B, Biswas R, Havel S, Prochazkova J, Sisakova A, et al.
Eur J Med Chem
. 2025 Jan;
285:117226.
PMID: 39793442
MRE11 nuclease is a central player in signaling and processing DNA damage, and in resolving stalled replication forks. Here, we describe the identification and characterization of new MRE11 inhibitors MU147...
3.
Sedlak D, Tuma R, Kolla J, Mokhamatam R, Bahrova L, Lisova M, et al.
J Mol Biol
. 2024 Nov;
437(2):168883.
PMID: 39608634
Transcription factors of the bHLH-PAS family play vital roles in animal development, physiology, and disease. Two members of the family require binding of low-molecular weight ligands for their activity: the...
4.
Delawska K, Hajek J, Voracova K, Kuzma M, Mares J, Vickova K, et al.
Org Biomol Chem
. 2024 Nov;
23(2):449-460.
PMID: 39576263
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are intriguing compounds with potential pharmacological applications. While many RiPPs are known as antimicrobial agents, a limited number of RiPPs with anti-proliferative effects...
5.
Oleksak P, Rysanek D, Vancurova M, Vasicova P, Urbancokova A, Novak J, et al.
ACS Pharmacol Transl Sci
. 2024 Sep;
7(9):2755-2783.
PMID: 39296273
6-Nitrobenzo[]thiophene 1,1-dioxide (Stattic) is a potent signal transducer and activator of the transcription 3 (STAT3) inhibitor developed originally for anticancer therapy. However, Stattic harbors several STAT3 inhibition-independent biological effects. To...
6.
Jindra M, Tumova S, Bittova L, Tuma R, Sedlak D
Curr Opin Insect Sci
. 2024 Jul;
65:101234.
PMID: 39025365
Juvenile hormone (JH) signaling is realized at the gene regulatory level by receptors of the bHLH-PAS transcription factor family. The sesquiterpenoid hormones and their synthetic mimics are agonist ligands of...
7.
Agea M, cmelo I, Dehaen W, Chen Y, Kirchmair J, Sedlak D, et al.
Mol Inform
. 2024 Jul;
43(8):e202300316.
PMID: 38979783
Computational exploration of chemical space is crucial in modern cheminformatics research for accelerating the discovery of new biologically active compounds. In this study, we present a detailed analysis of the...
8.
Munawar Cheema M, Macakova Kotrbova Z, Hrcka Krausova B, Adla S, Slavikova B, Chodounska H, et al.
J Steroid Biochem Mol Biol
. 2024 Jan;
239:106464.
PMID: 38246201
Endogenous neurosteroids (NS) and their synthetic analogs, neuroactive steroids (NAS), are potentially useful drug-like compounds affecting the pathophysiology of miscellaneous central nervous system disorders (e.g. Alzheimer´s disease, epilepsy, depression, etc.)....
9.
Souckova O, Skopova V, Baresova V, Sedlak D, Bleyer A, Kmoch S, et al.
Metabolites
. 2022 Dec;
12(12).
PMID: 36557247
Cytotoxicity of de novo purine synthesis (DNPS) metabolites is critical to the pathogenesis of three known and one putative autosomal recessive disorder affecting DNPS. These rare disorders are caused by...
10.
Tumova S, Milacek M, Snajdr I, Muthu M, Tuma R, reha D, et al.
Proc Natl Acad Sci U S A
. 2022 Nov;
119(48):e2215541119.
PMID: 36409882
Juvenile hormones (JHs) control insect metamorphosis and reproduction. JHs act through a receptor complex consisting of methoprene-tolerant (Met) and taiman (Tai) proteins to induce transcription of specific genes. Among chemically...