Leigh M Marsh
Overview
Explore the profile of Leigh M Marsh including associated specialties, affiliations and a list of published articles.
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Articles
75
Citations
1670
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Recent Articles
1.
Birnhuber A, Biasin V, Jain P, Kwiatkowski G, Boiarina E, Wilhelm J, et al.
Am J Physiol Lung Cell Mol Physiol
. 2025 Feb;
328(3):L413-L429.
PMID: 39903186
Lung vessel remodeling leads to increased pulmonary vascular resistance, causing pulmonary arterial hypertension (PAH), and consequently right ventricular hypertrophy and failure. In patients suffering from systemic sclerosis (SSc), PAH can...
2.
Fliesser E, Jandl K, Lins T, Birnhuber A, Valzano F, Kolb D, et al.
Am J Respir Cell Mol Biol
. 2024 Jun;
71(3):318-331.
PMID: 38843440
Pulmonary fibrosis (PF) can be a fatal disease characterized by progressive lung scarring. It is still poorly understood how the pulmonary endothelium is involved in the disease pathogenesis. Differences of...
3.
Mutgan A, Radic N, Valzano F, Crnkovic S, El-Merhie N, Evermann M, et al.
Am J Physiol Lung Cell Mol Physiol
. 2024 May;
327(2):L173-L188.
PMID: 38771138
Changes in the extracellular matrix of pulmonary arteries (PAs) are a key aspect of vascular remodeling in pulmonary hypertension (PH). Yet, our understanding of the alterations affecting the proteoglycan (PG)...
4.
Zeder K, Marsh L, Avian A, Brcic L, Birnhuber A, Douschan P, et al.
J Heart Lung Transplant
. 2024 Feb;
43(7):1090-1101.
PMID: 38382583
Background: In patients with end-stage chronic obstructive pulmonary disease (COPD), severe pulmonary hypertension (PH) is frequently associated with less severe airway obstruction as compared to mild or no PH. However,...
5.
Mutgan A, Jandl K, Radic N, Valzano F, Kolb D, Hoffmann J, et al.
Am J Physiol Cell Physiol
. 2023 Sep;
325(5):C1294-C1312.
PMID: 37694286
Deposition of basement membrane components, such as collagen IVα5, is associated with altered endothelial cell function in pulmonary hypertension. Collagen IVα5 harbors a functionally active fragment within its C-terminal noncollageneous...
6.
Borek I, Birnhuber A, Voelkel N, Marsh L, Kwapiszewska G
J Clin Invest
. 2023 Aug;
133(16).
PMID: 37581311
The pulmonary vasculature has been frequently overlooked in acute and chronic lung diseases, such as acute respiratory distress syndrome (ARDS), pulmonary fibrosis (PF), and chronic obstructive pulmonary disease (COPD). The...
7.
Durmus N, Chen W, Park S, Marsh L, Kwon S, Nolan A, et al.
Int J Mol Sci
. 2023 Aug;
24(15).
PMID: 37569308
Pulmonary hypertension (PH) has a high mortality and few treatment options. Adaptive immune mediators of PH in mice challenged with antigen/particulate matter (antigen/PM) has been the focus of our prior...
8.
Alhamdan F, Greulich T, Daviaud C, Marsh L, Pedersen F, Tholken C, et al.
Allergy
. 2023 Jul;
78(11):2944-2958.
PMID: 37486026
Rationale And Objective: Plasma extracellular vesicles (EVs) represent a vital source of molecular information about health and disease states. Due to their heterogenous cellular sources, EVs and their cargo may...
9.
Jandl K, Marsh L, Mutgan A, Crnkovic S, Valzano F, Zabini D, et al.
Am J Respir Crit Care Med
. 2023 Jan;
207(6):796-798.
PMID: 36638560
No abstract available.
10.
Crnkovic S, Rittchen S, Jandl K, Gindlhuber J, Zabini D, Mutgan A, et al.
Hypertension
. 2022 Dec;
80(2):e17-e28.
PMID: 36519465
Background: Smooth muscle cell (SMC) expansion is one key morphological hallmark of pathologically altered vasculature and a characteristic feature of pulmonary vascular remodeling in pulmonary hypertension. Normal embryonal vessel maturation...