Leigh C Murphy
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Explore the profile of Leigh C Murphy including associated specialties, affiliations and a list of published articles.
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59
Citations
1752
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Recent Articles
1.
Chatterjee S, Bhat V, Berdnikov A, Liu J, Zhang G, Buchel E, et al.
iScience
. 2019 Aug;
19:388-401.
PMID: 31419632
Breast cancer-induced activated fibroblasts support tumor progression. However, the role of normal fibroblasts in tumor progression remains controversial. In this study, we used modified patient-derived organoid cultures and demonstrate that...
2.
Basak P, Chatterjee S, Bhat V, Su A, Jin H, Lee-Wing V, et al.
Cell Physiol Biochem
. 2018 Nov;
51(4):1518-1532.
PMID: 30497079
Background/aims: Blocking estrogen signaling with endocrine therapies (Tamoxifen or Fulverstrant) is an effective treatment for Estrogen Receptor-α positive (ER+) breast cancer tumours. Unfortunately, development of endocrine therapy resistance (ETR) is...
3.
Chatterjee S, Basak P, Buchel E, Murphy L, Raouf A
Stem Cell Res Ther
. 2018 Oct;
9(1):264.
PMID: 30286804
Background: Normal human breast epithelial cells are maintained by the proliferation and differentiation of different human breast epithelial progenitors (HBEPs). However, these progenitor subsets can only be obtained at low...
4.
Chi C, Murphy L, Hu P
Oncotarget
. 2018 Mar;
9(14):11541-11558.
PMID: 29545918
Breast cancer diagnosis in young women has emerged as an independent prognostic factor with higher recurrence risk and death than their older counterparts. We aim to find recurrent somatic copy...
5.
Chatterjee S, Basak P, Buchel E, Safneck J, Murphy L, Mowat M, et al.
Stem Cell Reports
. 2017 Dec;
10(1):196-211.
PMID: 29233553
Human breast cancer cells are known to activate adjacent "normal-like" cells to enhance their own growth, but the cellular and molecular mechanisms involved are poorly understood. We now show by...
6.
Wang J, Duan Z, Nugent Z, Zou J, Borowsky A, Zhang Y, et al.
Cancer Lett
. 2016 May;
378(2):69-79.
PMID: 27164560
Metabolic reprogramming such as the aerobic glycolysis or Warburg effect is well recognized as a common feature of tumorigenesis. However, molecular mechanisms underlying metabolic alterations for tumor therapeutic resistance are...
7.
Zheng Y, Murphy L
Nucl Recept Signal
. 2016 Jan;
14:e001.
PMID: 26778927
Cell cycle progression is tightly controlled by several kinase families including Cyclin-Dependent Kinases, Polo-Like Kinases, and Aurora Kinases. A large amount of data show that steroid hormone receptors and various...
8.
Yan Y, Cooper C, Hamedani M, Guppy B, Xu W, Tsuyuki D, et al.
FEBS Lett
. 2015 Nov;
589(24 Pt B):4010-8.
PMID: 26581859
The steroid receptor RNA activator gene (SRA1) produces both a functional RNA (SRA) and a protein (SRAP), whose exact physiological roles remain unknown. To identify cellular processes regulated by SRAP...
9.
Basak P, Chatterjee S, Weger S, Bruce M, Murphy L, Raouf A
Endocr Relat Cancer
. 2015 May;
22(4):505-17.
PMID: 25944846
Although the role of estrogen signaling in breast cancer development has been extensively studied, the mechanisms that regulate the indispensable role of estrogen in normal mammary gland development have not...
10.
Murray J, West N, Murphy L, Watson P
Endocr Relat Cancer
. 2014 Nov;
22(1):R51-67.
PMID: 25404688
It is becoming clear that inflammation-associated mechanisms can affect progression of breast cancer and modulate responses to treatment. Estrogen receptor alpha (ERα (ESR1)) is the principal biomarker and therapeutic target...