Leena Kadam
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Explore the profile of Leena Kadam including associated specialties, affiliations and a list of published articles.
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28
Citations
371
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Recent Articles
1.
Velickovic M, Kadam L, Kim J, Zemaitis K, Velickovic D, Gao Y, et al.
Nat Commun
. 2025 Feb;
16(1):2061.
PMID: 40021619
The placenta is a complex and heterogeneous organ that links the mother and fetus, playing a crucial role in nourishing and protecting the fetus throughout pregnancy. Integrative spatial multi-omics approaches...
2.
Paquette A, Parenti M, Lapehn S, Konwar C, Kadam L, Firsick E, et al.
Placenta
. 2025 Jan;
160:29-38.
PMID: 39755094
Introduction: The placenta produces corticotrophin releasing hormone (CRH), which rises exponentially in maternal plasma across pregnancy. CRH plays a functional role in fetal development, labor initiation, and the regulation of...
3.
Kadam L, Velickovic M, Stratton K, Nicora C, Kyle J, Wang E, et al.
Placenta
. 2024 Dec;
159():76-83.
PMID: 39662110
Introduction: The placenta uses lipids and other nutrients to support its own metabolism hence impacting the type and amount of these substrates available to the growing fetus. Maternal obesity and...
4.
Lapehn S, Nair S, Firsick E, MacDonald J, Thoreson C, Litch J, et al.
Placenta
. 2024 Dec;
159:52-61.
PMID: 39637677
Introduction: Selecting an in vitro culture model of the human placenta is challenging due to representation of different trophoblast cell types with distinct biological roles and limited comparative studies that...
5.
Kadam L, Velickovic M, Stratton K, Nicora C, Kyle J, Wang E, et al.
bioRxiv
. 2024 Aug;
PMID: 39211280
Introduction: Obesity and gestational diabetes (GDM) are associated with adverse pregnancy outcomes and program the offspring for cardiometabolic disease in a sexually dimorphic manner. The placenta transfers lipids to the...
6.
Paquette A, Ahuna K, Hwang Y, Pearl J, Liao H, Shannon P, et al.
Sci Adv
. 2024 Jun;
10(26):eadf3411.
PMID: 38941464
Gene regulation is essential to placental function and fetal development. We built a genome-scale transcriptional regulatory network (TRN) of the human placenta using digital genomic footprinting and transcriptomic data. We...
7.
Phillips E, Alharithi Y, Kadam L, Coussens L, Kumar S, Maloyan A
Int J Obes (Lond)
. 2024 Jun;
48(11):1542-1551.
PMID: 38937647
Background/objectives: Intrauterine metabolic reprogramming occurs in mothers with obesity during gestation, putting the offspring at high risk of developing obesity and associated metabolic disorders even before birth. We have generated...
8.
Lapehn S, Nair S, Firsick E, MacDonald J, Thoreson C, Litch J, et al.
bioRxiv
. 2024 Jun;
PMID: 38915703
Studying the human placenta through in vitro cell culture methods is necessary due to limited access and amenability of human placental tissue to certain experimental methods as well as distinct...
9.
Alina M, Phillips E, Alharithi Y, Kadam L, Coussens L, Kumar S
Res Sq
. 2024 Feb;
PMID: 38313293
Intrauterine metabolic reprogramming occurs in obese mothers during gestation, putting the offspring at high risk of developing obesity and associated metabolic disorders even before birth. We have generated a mouse...
10.
Phillips E, Alharithi Y, Kadam L, Coussens L, Kumar S, Maloyan A
bioRxiv
. 2023 Dec;
PMID: 38077037
Intrauterine metabolic reprogramming occurs in obese mothers during gestation, putting the offspring at high risk of developing obesity and associated metabolic disorders even before birth. We have generated a mouse...