Lee-Yuan Liu-Chen
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Explore the profile of Lee-Yuan Liu-Chen including associated specialties, affiliations and a list of published articles.
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112
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2402
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Recent Articles
1.
Huang P, Ho C, Bland K, Liu-Chen L
Neurosci Lett
. 2025 Feb;
850:138154.
PMID: 39923977
We previously demonstrated that in a mouse line expressing a kappa opioid receptor (KOR) mutant with all the four phosphorylation sites mutated to alanines (K4A) the selective KOR agonist U50,488H...
2.
Bland K, Chen C, Huang P, Ho C, Howe T, Ocampo K, et al.
Neuropharmacology
. 2025 Jan;
268:110316.
PMID: 39863270
Akuammicine (AKC), an indole alkaloid, is a kappa opioid receptor (KOR) full agonist with a moderate affinity. 10-Iodo-akuammicine (I-AKC) and 10-Bromo-akuammicine (Br-AKC) showed higher affinities for the KOR with K...
3.
Li Y, Cotham W, Eliasof A, Bland K, Walla M, Pellechia P, et al.
Int J Mol Sci
. 2024 Nov;
25(21).
PMID: 39518941
CycloAnt is an opioid peptide that produces potent and efficacious antinociception with significantly reduced side effects upon systemic administration in mice. To verify its CNS-mediated antinociception, we determined its binding...
4.
Eliasof A, Liu-Chen L, Li Y
Drug Discov Today
. 2024 Mar;
29(5):103950.
PMID: 38514040
Drugs targeting the μ-opioid receptor (MOR) remain the most efficacious analgesics for the treatment of pain, but activation of MOR with current opioid analgesics also produces harmful side effects, notably...
5.
Huang P, Ho C, Cao D, Inan S, Rawls S, Li M, et al.
J Pharmacol Exp Ther
. 2024 Feb;
389(1):106-117.
PMID: 38409113
While agonists of (MOR) and (KOR) opioid receptors have analgesic effects, they produce euphoria and dysphoria, respectively. Other side effects include respiratory depression and addiction for MOR agonists and sedation...
6.
Toussaint A, Ellis A, Bongiovanni A, Peterson D, Bavley C, Karbalaei R, et al.
bioRxiv
. 2023 Jan;
PMID: 36711571
Background: A growing body of preclinical studies report that preconceptional experiences can have a profound and long-lasting impact on adult offspring behavior and physiology. However, less is known about paternal...
7.
Mengaziol J, Dunn A, Salimando G, Wooldridge L, Crues-Muncunill J, Eacret D, et al.
PLoS One
. 2022 Dec;
17(12):e0270317.
PMID: 36534642
Key targets of both the therapeutic and abused properties of opioids are μ-opioid receptors (MORs). Despite years of research investigating the biochemistry and signal transduction pathways associated with MOR activation,...
8.
Liu-Chen L, Huang P
Front Neurosci
. 2022 Nov;
16:964724.
PMID: 36408401
Kappa opioid receptor (KOR) agonists are potentially useful as analgesic and anti-pruritic agents, for prevention and treatment of substance use disorders, and for treatment of demyelinating diseases. However, side effects...
9.
Shi X, von Weltin E, Fitzsimmons E, Do C, Caban Rivera C, Chen C, et al.
Front Pharmacol
. 2022 Oct;
13:976932.
PMID: 36238569
Mechanistic target of rapamycin (mTOR) C1 and its downstream effectors have been implicated in synaptic plasticity and memory. Our prior work demonstrated that reactivation of cocaine memory engages a signaling...
10.
Chen C, Huang P, Bland K, Li M, Zhang Y, Liu-Chen L
Front Pharmacol
. 2022 Jun;
13:835809.
PMID: 35652052
Selective kappa opioid receptor (KOR) agonists are promising antipruritic agents and analgesics. However, clinical development of KOR agonists has been limited by side effects, including psychotomimetic effects, dysphoria, and sedation,...