Lauris Kaplinski
Overview
Explore the profile of Lauris Kaplinski including associated specialties, affiliations and a list of published articles.
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Articles
24
Citations
423
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0
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Recent Articles
1.
Kaplinski L, Mols M, Puurand T, Remm M
Bioinform Adv
. 2023 Aug;
3(1):vbad084.
PMID: 37641716
Motivation: Accurate estimation of next-generation sequencing depth of coverage is needed for detecting the copy number of repeated elements in the human genome. The common methods for estimating sequencing depth...
2.
Kaplinski L, Mols M, Puurand T, Pajuste F, Remm M
Hum Mutat
. 2021 Mar;
42(6):777-786.
PMID: 33715282
KATK is a fast and accurate software tool for calling variants directly from raw next-generation sequencing reads. It uses predefined k-mers to retrieve only the reads of interest from the...
3.
Zilina O, Rekker K, Kaplinski L, Sauk M, Paluoja P, Teder H, et al.
Prenat Diagn
. 2019 Nov;
39(13):1262-1268.
PMID: 31691324
Objective: The study aimed to validate a whole-genome sequencing-based NIPT laboratory method and our recently developed NIPTmer aneuploidy detection software with the potential to integrate the pipeline into prenatal clinical...
4.
Sauk M, Zilina O, Kurg A, Ustav E, Peters M, Paluoja P, et al.
Sci Rep
. 2018 Apr;
8(1):5616.
PMID: 29618827
Non-invasive prenatal testing (NIPT) is a recent and rapidly evolving method for detecting genetic lesions, such as aneuploidies, of a fetus. However, there is a need for faster and cheaper...
5.
Koressaar T, Lepamets M, Kaplinski L, Raime K, Andreson R, Remm M
Bioinformatics
. 2018 Jan;
34(11):1937-1938.
PMID: 29360956
Summary: Designing PCR primers for amplifying regions of eukaryotic genomes is a complicated task because the genomes contain a large number of repeat sequences and other regions unsuitable for amplification...
6.
Pajuste F, Kaplinski L, Mols M, Puurand T, Lepamets M, Remm M
Sci Rep
. 2017 Jun;
7(1):2537.
PMID: 28566690
We have developed a computational method that counts the frequencies of unique k-mers in FASTQ-formatted genome data and uses this information to infer the genotypes of known variants. FastGT can...
7.
Roosaare M, Vaher M, Kaplinski L, Mols M, Andreson R, Lepamets M, et al.
PeerJ
. 2017 May;
5:e3353.
PMID: 28533988
Background: Fast, accurate and high-throughput identification of bacterial isolates is in great demand. The present work was conducted to investigate the possibility of identifying isolates from unassembled next-generation sequencing reads...
8.
Sillaste G, Kaplinski L, Meier R, Jaakma U, Eriste E, Salumets A
Reproduction
. 2016 Dec;
153(3):241-251.
PMID: 27899719
DNA compaction with protamines in sperm is essential for successful fertilization. However, a portion of sperm chromatin remains less tightly packed with histones, which genomic location and function remain unclear....
9.
Kaplinski L, Lepamets M, Remm M
Gigascience
. 2015 Dec;
4:58.
PMID: 26640690
Background: K-mer-based methods of genome analysis have attracted great interest because they do not require genome assembly and can be performed directly on sequencing reads. Many analysis tasks require one...
10.
Palta P, Kaplinski L, Nagirnaja L, Veidenberg A, Mols M, Nelis M, et al.
PLoS One
. 2015 Apr;
10(4):e0122713.
PMID: 25853576
DNA copy number variants (CNVs) that alter the copy number of a particular DNA segment in the genome play an important role in human phenotypic variability and disease susceptibility. A...