Laurin M Hanft
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Explore the profile of Laurin M Hanft including associated specialties, affiliations and a list of published articles.
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26
Citations
445
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Recent Articles
1.
Behrmann A, Cayton J, Hayden M, Lambert M, Nourian Z, Nyanyo K, et al.
Physiol Rep
. 2024 Apr;
12(8):e16004.
PMID: 38658324
Duchenne muscular dystrophy (DMD) is an X-linked recessive myopathy due to mutations in the dystrophin gene. Diaphragmatic weakness in DMD causes hypoventilation and elevated afterload on the right ventricle (RV)....
2.
Haffner V, Nourian Z, Boerman E, Lambert M, Hanft L, Krenz M, et al.
Am J Physiol Heart Circ Physiol
. 2023 Sep;
325(5):H1168-H1177.
PMID: 37737731
Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy and is caused by mutations in the dystrophin gene. Dystrophin deficiency is associated with structural and functional changes of the...
3.
Perike S, Gonzalez-Gonzalez F, Abu-Taha I, Damen F, Hanft L, Lizama K, et al.
Circ Res
. 2023 Sep;
133(9):758-771.
PMID: 37737016
Background: Atrial fibrillation (AF)-the most common sustained cardiac arrhythmia-increases thromboembolic stroke risk 5-fold. Although atrial hypocontractility contributes to stroke risk in AF, the molecular mechanisms reducing myofilament contractile function remain...
4.
George T, Hanft L, Krenz M, Domeier T, McDonald K
Front Physiol
. 2023 Jun;
14:1207658.
PMID: 37362434
Dystrophic cardiomyopathy arises from mutations in the dystrophin gene. Dystrophin forms part of the dystrophin glycoprotein complex and is postulated to act as a membrane stabilizer, protecting the sarcolemma from...
5.
Hanft L, Robinett J, Kalogeris T, Campbell K, Biesiadecki B, McDonald K
J Gen Physiol
. 2023 Mar;
155(5).
PMID: 37000170
The heart's pumping capacity is determined by myofilament power generation. Power is work done per unit time and measured as the product of force and velocity. At a sarcomere level,...
6.
Robinett J, Hanft L, Biesiadecki B, McDonald K
Am J Physiol Cell Physiol
. 2022 Oct;
323(6):C1728-C1739.
PMID: 36280392
Stretch activation is defined as a delayed increase in force after rapid stretches. Although there is considerable evidence for stretch activation in isolated cardiac myofibrillar preparations, few studies have measured...
7.
Hanft L, Fitzsimons D, Hacker T, Moss R, McDonald K
J Gen Physiol
. 2021 Mar;
153(7).
PMID: 33646280
The Frank-Starling relationship establishes that elevated end-diastolic volume progressively increases ventricular pressure and stroke volume in healthy hearts. The relationship is modulated by a number of physiological inputs and is...
8.
McDonald K, Hanft L, Robinett J, Guglin M, Campbell K
Front Physiol
. 2020 Jun;
11:468.
PMID: 32523542
Heart failure (HF) often includes changes in myocardial contractile function. This study addressed the myofibrillar basis for contractile dysfunction in failing human myocardium. Regulation of contractile properties was measured in...
9.
Robinett J, Hanft L, Geist J, Kontrogianni-Konstantopoulos A, McDonald K
J Gen Physiol
. 2019 Feb;
151(5):645-659.
PMID: 30705121
Myosin binding protein C (MyBP-C) is a 125-140-kD protein located in the C-zone of each half-thick filament. It is thought to be an important regulator of contraction, but its precise...
10.
Hanft L, McDonald K
Arch Biochem Biophys
. 2019 Jan;
663:160-164.
PMID: 30639328
No abstract available.