Laurie J Gordon
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Explore the profile of Laurie J Gordon including associated specialties, affiliations and a list of published articles.
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22
Citations
174
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Recent Articles
1.
Hirst D, Bamborough P, Al-Mahdi N, Angell D, Barnett H, Baxter A, et al.
J Med Chem
. 2024 Jun;
67(12):10464-10489.
PMID: 38866424
The bromodomain and extra terminal (BET) family of bromodomain-containing proteins are important epigenetic regulators that elicit their effect through binding histone tail -acetyl lysine (KAc) post-translational modifications. Recognition of such...
2.
Lay C, Thomas D, Evans J, Campbell M, McCombe K, Phillipou A, et al.
Cell Chem Biol
. 2023 Dec;
30(12):1692.
PMID: 38134882
No abstract available.
3.
Humphreys P, Anderson N, Bamborough P, Baxter A, Chung C, Cookson R, et al.
J Med Chem
. 2022 Nov;
65(22):15174-15207.
PMID: 36378954
The bromodomain and extra terminal (BET) family of proteins are an integral part of human epigenome regulation, the dysregulation of which is implicated in multiple oncology and inflammatory diseases. Disrupting...
4.
Humphreys P, Atkinson S, Bamborough P, Bit R, Chung C, Craggs P, et al.
J Med Chem
. 2022 Jan;
65(3):2262-2287.
PMID: 34995458
Through regulation of the epigenome, the bromodomain and extra terminal (BET) family of proteins represent important therapeutic targets for the treatment of human disease. Through mimicking the endogenous -acetyl-lysine group...
5.
Lay C, Thomas D, Evans J, Campbell M, McCombe K, Phillipou A, et al.
Cell Chem Biol
. 2021 Sep;
29(2):287-299.e8.
PMID: 34520747
Contemporary drug discovery typically quantifies the effect of a molecule on a biological target using the equilibrium-derived measurements of IC, EC, or K. Kinetic descriptors of drug binding are frequently...
6.
Miah A, Smith I, Rackham M, Mares A, Thawani A, Nagilla R, et al.
J Med Chem
. 2021 Aug;
64(17):12978-13003.
PMID: 34432979
Receptor-interacting serine/threonine protein kinase 2 (RIPK2) is an important kinase of the innate immune system. Herein, we describe the optimization of a series of RIPK2 PROTACs which recruit members of...
7.
Clegg M, Theodoulou N, Bamborough P, Chung C, Craggs P, Demont E, et al.
ACS Med Chem Lett
. 2021 Aug;
12(8):1308-1317.
PMID: 34413961
Bromodomain containing proteins and the acetyl-lysine binding bromodomains contained therein are increasingly attractive targets for the development of novel epigenetic therapeutics. To help validate this target class and unravel the...
8.
Preston A, Atkinson S, Bamborough P, Chung C, Gordon L, Grandi P, et al.
ACS Med Chem Lett
. 2020 Aug;
11(8):1581-1587.
PMID: 32832027
Pan-BET inhibitors have shown profound efficacy in a number of in vivo preclinical models and have entered the clinic in oncology trials where adverse events have been reported. These inhibitors...
9.
Phillipou A, Lay C, Carver C, Messenger C, Evans J, Lewis A, et al.
SLAS Discov
. 2019 Dec;
25(2):163-175.
PMID: 31875412
Malfunctions in the basic epigenetic mechanisms such as histone modifications, DNA methylation, and chromatin remodeling are implicated in a number of cancers and immunological and neurodegenerative conditions. Within GlaxoSmithKline (GSK)...
10.
Law R, Atkinson S, Bamborough P, Chung C, Demont E, Gordon L, et al.
J Med Chem
. 2018 Apr;
61(10):4317-4334.
PMID: 29656650
The bromodomain and extra-terminal domain (BET) family of proteins bind acetylated lysine residues on histone proteins. The four BET bromodomains-BRD2, BRD3, BRD4, and BRDT-each contain two bromodomain modules. BET bromodomain...