Laurie E Littlepage
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Explore the profile of Laurie E Littlepage including associated specialties, affiliations and a list of published articles.
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32
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1744
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Recent Articles
1.
Alderfer L, Saha S, Fan F, Wu J, Littlepage L, Hanjaya-Putra D
Commun Biol
. 2024 Oct;
7(1):1262.
PMID: 39367247
Controlling the formation of new lymphatic vessels has been postulated as an innovative therapeutic strategy for various disease phenotypes, including neurodegenerative diseases, metabolic syndrome, cardiovascular disease, and lymphedema. Yet, compared...
2.
Charlestin V, Tan E, Arias-Matus C, Wu J, Miranda-Vergara M, Lee M, et al.
Cancers (Basel)
. 2024 Aug;
16(15).
PMID: 39123442
AQPs contribute to breast cancer progression and metastasis. We previously found that genetic inhibition of Aqp7 reduces primary tumor burden and metastasis in breast cancer. In this study, we utilized...
3.
Controlled mechanical loading affects the osteocyte transcriptome in porcine trabecular bone in situ
Machireddy M, Oberman A, DeBiase L, Stephens M, Li J, Littlepage L, et al.
Bone
. 2024 Feb;
181:117028.
PMID: 38309412
Introduction: Osteocytes modulate bone adaptation in response to mechanical stimuli imparted by the deforming bone tissue in which they are encased by communicating with osteoclasts and osteoblasts as well as...
4.
Khan S, Mejia F, Shin J, Hwang G, Omstead D, Wu J, et al.
Biomaterials
. 2022 Nov;
292:121913.
PMID: 36442437
Here, we report a CD138 receptor targeting liposomal formulation (TNP[Prodrug-4]) that achieved efficacious tumor growth inhibition in treating multiple myeloma by overcoming the dose limiting severe toxicity issues of a...
5.
Charlestin V, Fulkerson D, Arias Matus C, Walker Z, Carthy K, Littlepage L
Front Oncol
. 2022 Oct;
12:988119.
PMID: 36212456
Aquaporins (AQPs) are a family of small transmembrane proteins that selectively transport water and other small molecules and ions following an osmotic gradient across cell plasma membranes. This enables them...
6.
Curtis K, Mai C, Martin H, Oberman A, Alderfer L, Romero-Moreno R, et al.
Mol Biol Cell
. 2021 Mar;
32(10):1009-1019.
PMID: 33689396
Metastasis is responsible for over 90% of cancer-related deaths, and bone is the most common site for breast cancer metastasis. Metastatic breast cancer cells home to trabecular bone, which contains...
7.
Omstead D, Mejia F, Sjoerdsma J, Kim B, Shin J, Khan S, et al.
J Hematol Oncol
. 2020 Nov;
13(1):145.
PMID: 33138841
Background: Drug-loaded nanoparticles have established their benefits in the fight against multiple myeloma; however, ligand-targeted nanomedicine has yet to successfully translate to the clinic due to insufficient efficacies reported in...
8.
Northey J, Barrett A, Acerbi I, Hayward M, Talamantes S, Dean I, et al.
J Clin Invest
. 2020 Jul;
130(11):5721-5737.
PMID: 32721948
Women with dense breasts have an increased lifetime risk of malignancy that has been attributed to a higher epithelial density. Quantitative proteomics, collagen analysis, and mechanical measurements in normal tissue...
9.
Dai C, Charlestin V, Wang M, Walker Z, Miranda-Vergara M, Facchine B, et al.
Cancer Res
. 2020 Jul;
80(19):4071-4086.
PMID: 32631905
The complex yet interrelated connections between cancer metabolism, gene expression, and oncogenic driver genes have the potential to identify novel biomarkers and drug targets with prognostic and therapeutic value. Here...
10.
Kim B, Shin J, Wu J, Omstead D, Kiziltepe T, Littlepage L, et al.
J Control Release
. 2020 Apr;
322:530-541.
PMID: 32276005
Here, we report rationally engineered peptide-targeted liposomal doxorubicin nanoparticles that have an enhanced selectivity for HER2-positive breast tumor cells with high purity, reproducibility, and precision in controlling stoichiometry of targeting...