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Laurie Destroismaisons

Explore the profile of Laurie Destroismaisons including associated specialties, affiliations and a list of published articles. Areas
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Citations 585
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Recent Articles
1.
Semmler S, Gagne M, Garg P, Pickles S, Baudouin C, Hamon-Keromen E, et al.
J Biol Chem . 2020 Feb; 295(12):3808-3825. PMID: 32029478
Amyotrophic lateral sclerosis (ALS) is a fatal disease, characterized by the selective loss of motor neurons leading to paralysis. Mutations in the gene encoding superoxide dismutase 1 (SOD1) are the...
2.
Deshaies J, Shkreta L, Moszczynski A, Sidibe H, Semmler S, Fouillen A, et al.
Brain . 2018 Mar; 141(5):1320-1333. PMID: 29562314
See Fratta and Isaacs (doi:10.1093/brain/awy091) for a scientific commentary on this article.The RNA binding proteins TDP-43 (encoded by TARDBP) and hnRNP A1 (HNRNPA1) are each mutated in certain amyotrophic lateral...
3.
Chiasseu M, Alarcon-Martinez L, Belforte N, Quintero H, Dotigny F, Destroismaisons L, et al.
Mol Neurodegener . 2017 Aug; 12(1):58. PMID: 28774322
Background: Tau is an axon-enriched protein that binds to and stabilizes microtubules, and hence plays a crucial role in neuronal function. In Alzheimer's disease (AD), pathological tau accumulation correlates with...
4.
Chiasseu M, Cueva Vargas J, Destroismaisons L, Vande Velde C, Leclerc N, Di Polo A
J Neurosci . 2016 May; 36(21):5785-98. PMID: 27225768
Unlabelled: Glaucoma, the leading cause of irreversible blindness worldwide, is characterized by the selective death of retinal ganglion cells (RGCs). Ocular hypertension is the most significant known risk factor for...
5.
Pickles S, Semmler S, Broom H, Destroismaisons L, Legroux L, Arbour N, et al.
Acta Neuropathol Commun . 2016 Apr; 4(1):43. PMID: 27121871
Approximately 20 % of familial Amyotrophic Lateral Sclerosis (ALS) is caused by mutations in superoxide dismutase (SOD1), which leads to misfolding of the SOD1 protein, resulting in a toxic gain...
6.
Aulas A, Caron G, Gkogkas C, Mohamed N, Destroismaisons L, Sonenberg N, et al.
J Cell Biol . 2015 Apr; 209(1):73-84. PMID: 25847539
G3BP1, a target of TDP-43, is required for normal stress granule (SG) assembly, but the functional consequences of failed SG assembly remain unknown. Here, using both transformed cell lines and...
7.
Pickles S, Cadieux-Dion M, Alvarez J, Lecuyer M, Peyrard S, Destroismaisons L, et al.
PLoS One . 2013 Sep; 8(9):e74603. PMID: 24019971
Blood vessel-specific fluorescent transgenic mice are excellent tools to study the development of the vasculature and angiogenic processes. There is growing interest in the biological processes relevant to endothelial cells...
8.
Pickles S, Destroismaisons L, Peyrard S, Cadot S, Rouleau G, Brown Jr R, et al.
Hum Mol Genet . 2013 Jun; 22(19):3947-59. PMID: 23736301
Mutant superoxide dismutase 1 (SOD1) selectively associates with spinal cord mitochondria in rodent models of SOD1-mediated amyotrophic lateral sclerosis. A portion of mutant SOD1 exists in a non-native/misfolded conformation that...
9.
Bannwarth S, Figueroa A, Fragaki K, Destroismaisons L, Lacas-Gervais S, Lespinasse F, et al.
Mitochondrion . 2012 Aug; 12(6):654-65. PMID: 22917773
MutS homologs play a central role in maintaining genetic stability. We show that MSH5 (MutSHomolog 5) is localized into the mitochondria of germ and somatic cells. This protein binds to...
10.
McDonald K, Aulas A, Destroismaisons L, Pickles S, Beleac E, Camu W, et al.
Hum Mol Genet . 2011 Jan; 20(7):1400-10. PMID: 21257637
TAR deoxyribonucleic acid-binding protein 43 (TDP-43) is a multifunctional protein with roles in transcription, pre-messenger ribonucleic acid (mRNA) splicing, mRNA stability and transport. TDP-43 interacts with other heterogeneous nuclear ribonucleoproteins...