Laurent Delpy
Overview
Explore the profile of Laurent Delpy including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
693
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Recent Articles
1.
Haas M, Cherfa S, Nguyen L, Bourgoin M, Caron G, Dessauge E, et al.
Nat Commun
. 2025 Jan;
16(1):256.
PMID: 39747141
Our study explores the complex dynamics of the integrated stress response (ISR) axis, highlighting PIM2 kinase's critical role and its interaction with the BCL2 protein family, uncovering key mechanisms of...
2.
Haas M, Caron G, Chatonnet F, Manenti S, Alaterre E, Devin J, et al.
Blood
. 2022 Feb;
139(15):2316-2337.
PMID: 35108359
The differentiation of B cells into plasmablasts (PBs) and then plasma cells (PCs) is associated with extensive cell reprogramming and new cell functions. By using specific inhibition strategies (including a...
3.
Marchalot A, Horiot C, Lambert J, Carrion C, Oblet C, Pollet J, et al.
J Allergy Clin Immunol
. 2021 Nov;
149(5):1795-1801.
PMID: 34740604
Background: Allergy regroups numerous complex and various diseases classified as IgE-dependent or non-IgE-dependent hypersensitivities. IgEs are expressed as membrane and secreted forms by B cells and plasma cells, respectively. In...
4.
Baylet A, Vyumvuhore R, Laclaverie M, Marchand L, Mainzer C, Bordes S, et al.
Allergy Asthma Clin Immunol
. 2021 Jul;
17(1):73.
PMID: 34281610
Currently, several biologics are used for the treatment of cutaneous pathologies such as atopic dermatitis (AD), psoriasis or skin cancers. The main administration routes are subcutaneous and intravenous injections. However,...
5.
Baylet A, Laclaverie M, Marchand L, Bordes S, Closs-Gonthier B, Delpy L
Drug Discov Today
. 2020 Nov;
26(1):248-255.
PMID: 33137480
Skin is a vital protective organ, the main role of which is to provide a physical barrier and to prevent the entry of pathogens. Various pathologies, such as atopic dermatitis...
6.
Bender S, Ayala M, Bonaud A, Javaugue V, Carrion C, Oblet C, et al.
Blood
. 2020 Jun;
136(14):1645-1656.
PMID: 32559766
Light chain (LC) deposition disease (LCDD) is a rare disorder characterized by glomerular and peritubular amorphous deposits of a monoclonal immunoglobulin LC, leading to nodular glomerulosclerosis and nephrotic syndrome. We...
7.
Marchalot A, Ashi M, Lambert J, Carrion C, Lecardeur S, Srour N, et al.
Front Immunol
. 2020 Jun;
11:780.
PMID: 32477332
Class switch recombination (CSR) changes antibody isotype by replacing Cμ constant exons with different constant exons located downstream on the immunoglobulin heavy () locus. During CSR, transcription through specific switch...
8.
Lambert J, Ashi M, Srour N, Delpy L, Sauliere J
Int J Mol Sci
. 2020 Feb;
21(4).
PMID: 32079193
The presence of premature termination codons (PTCs) in transcripts is dangerous for the cell as they encode potentially deleterious truncated proteins that can act with dominant-negative or gain-of-function effects. To...
9.
Lambert J, Srour N, Delpy L
BMB Rep
. 2019 Oct;
52(12):671-678.
PMID: 31619318
The random V(D)J recombination process ensures the diversity of the primary immunoglobulin (Ig) repertoire. In two thirds of cases, imprecise recombination between variable (V), diversity (D), and joining (J) segments...
10.
Cresson C, Peron S, Jamrog L, Rouquie N, Prade N, Dubois M, et al.
Oncotarget
. 2018 Sep;
9(67):32841-32854.
PMID: 30214688
Pax5 is the guardian of the B cell identity since it primes or enhances the expression of B cell specific genes and concomitantly represses the expression of B cell inappropriate...