Laurence S David
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Explore the profile of Laurence S David including associated specialties, affiliations and a list of published articles.
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13
Citations
305
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Recent Articles
1.
Bellavance J, David L, Hildebrand M
J Neurosci Res
. 2024 Dec;
102(12):e70008.
PMID: 39673257
Chronic pain is a highly debilitating condition that differs by type, prevalence, and severity between men and women. To uncover the molecular underpinnings of these differences, it is critical to...
2.
Antunes F, Gandini M, Gadotti V, Quintao N, Santin J, Souza I, et al.
Br J Pharmacol
. 2024 Sep;
181(24):5062-5078.
PMID: 39295452
Background And Purpose: The chemotherapy agent oxaliplatin can give rise to oxaliplatin-induced peripheral neuropathy (OIPN). Here, we investigated whether T-type calcium channels (Ca3) contribute to OIPN. Experimental Approach: We chronically...
3.
Farrell J, Gaxiola-Valdez I, Wolff M, David L, Dika H, Geeraert B, et al.
Elife
. 2016 Nov;
5.
PMID: 27874832
Seizures are often followed by sensory, cognitive or motor impairments during the postictal phase that show striking similarity to transient hypoxic/ischemic attacks. Here we show that seizures result in a...
4.
David L, Aitoubah J, Lesperance L, Wang L
Mol Brain
. 2014 Jul;
7:51.
PMID: 25063346
Background: Manipulation of gene expression via recombinant viral vectors and creation of transgenic knock-out/in animals has revolutionized our understanding of genes that play critical roles during neuronal development and pathophysiology...
5.
David L, Garcia E, Cain S, Thau E, Tyson J, Snutch T
Channels (Austin)
. 2010 Aug;
4(5):375-89.
PMID: 20699644
Low voltage-activated T-type calcium (Ca) channels contribute to the normal development of the heart and are also implicated in pathophysiological states such as cardiac hypertrophy. Functionally distinct T-type Ca channel...
6.
Nicholson R, David L, le Pan R, Liu X
Fitoterapia
. 2010 May;
81(7):826-9.
PMID: 20472040
This investigation focuses on the in vitro neuroactive properties of pinostrobin, a substituted flavanone from Cajanus cajan (L.) Millsp. of the Fabaceae family. We demonstrate that pinostrobin inhibits voltage-gated sodium...
7.
Adams P, Garcia E, David L, Mulatz K, Spacey S, Snutch T
Channels (Austin)
. 2009 Feb;
3(2):110-21.
PMID: 19242091
Alternative splicing is known to generate multiple functionally distinct calcium channel variants that exhibit unique spatial and temporal expression patterns. In humans, naturally occurring mutations in genes encoding calcium channel...
8.
Powell K, Cain S, Ng C, Sirdesai S, David L, Kyi M, et al.
J Neurosci
. 2009 Jan;
29(2):371-80.
PMID: 19144837
Low-voltage-activated, or T-type, calcium (Ca(2+)) channels are believed to play an essential role in the generation of absence seizures in the idiopathic generalized epilepsies (IGEs). We describe a homozygous, missense,...
9.
Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate
Nelson M, Joksovic P, Su P, Kang H, Van Deusen A, Baumgart J, et al.
J Neurosci
. 2007 Nov;
27(46):12577-83.
PMID: 18003836
T-type Ca2+ channels (T-channels) are involved in the control of neuronal excitability and their gating can be modulated by a variety of redox agents. Ascorbate is an endogenous redox agent...
10.
Hildebrand M, David L, Hamid J, Mulatz K, Garcia E, Zamponi G, et al.
J Biol Chem
. 2007 May;
282(29):21043-55.
PMID: 17535809
T-type calcium channels play critical roles in controlling neuronal excitability, including the generation of complex spiking patterns and the modulation of synaptic plasticity, although the mechanisms and extent to which...