Brandon Faubert
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Explore the profile of Brandon Faubert including associated specialties, affiliations and a list of published articles.
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48
Citations
7240
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Recent Articles
1.
Cai L, Hammond N, Tasdogan A, Alsamraae M, Yang C, Cameron R, et al.
Cancer Discov
. 2025 Feb;
:OF1-OF15.
PMID: 39960461
Intraoperative 13C-glucose infusions in patients with NSCLC show that tumors with high labeling of TCA cycle intermediates progress rapidly, resulting in metastasis and early death. Blocking this pathway suppresses metastasis...
2.
Lee H, Muhammad N, Lieu E, Cai F, Mu J, Ha Y, et al.
Nat Metab
. 2024 Jun;
6(7):1310-1328.
PMID: 38877143
Non-small-cell lung cancer (NSCLC) with concurrent mutations in KRAS and the tumour suppressor LKB1 (KL NSCLC) is refractory to most therapies and has one of the worst predicted outcomes. Here...
3.
Wu Z, Bezwada D, Cai F, Harris R, Ko B, Sondhi V, et al.
Cell Metab
. 2024 Jun;
36(7):1504-1520.e9.
PMID: 38876105
Mitochondria house many metabolic pathways required for homeostasis and growth. To explore how human cells respond to mitochondrial dysfunction, we performed metabolomics in fibroblasts from patients with various mitochondrial disorders...
4.
Feng Q, Bennett Z, Grichuk A, Pantoja R, Huang T, Faubert B, et al.
Nat Biomed Eng
. 2024 Mar;
8(6):787-799.
PMID: 38438799
Extracellular pH impacts many molecular, cellular and physiological processes, and hence is tightly regulated. Yet, in tumours, dysregulated cancer cell metabolism and poor vascular perfusion cause the tumour microenvironment to...
5.
Fan H, Xia S, Xiang J, Li Y, Ross M, Lim S, et al.
Nature
. 2023 Nov;
623(7989):1034-1043.
PMID: 37993715
Diet-derived nutrients are inextricably linked to human physiology by providing energy and biosynthetic building blocks and by functioning as regulatory molecules. However, the mechanisms by which circulating nutrients in the...
6.
Bartman C, Faubert B, Rabinowitz J, DeBerardinis R
Nat Rev Cancer
. 2023 Nov;
23(12):863-878.
PMID: 37907620
Metabolic reprogramming is central to malignant transformation and cancer cell growth. How tumours use nutrients and the relative rates of reprogrammed pathways are areas of intense investigation. Tumour metabolism is...
7.
Mukherjee A, Bezwada D, Greco F, Zandbergen M, Shen T, Chiang C, et al.
Nat Metab
. 2023 Aug;
5(9):1563-1577.
PMID: 37653041
In the tumor microenvironment, adipocytes function as an alternate fuel source for cancer cells. However, whether adipocytes influence macromolecular biosynthesis in cancer cells is unknown. Here we systematically characterized the...
8.
Wu Z, Bezwada D, Harris R, Pan C, Nguyen P, Faubert B, et al.
bioRxiv
. 2023 May;
PMID: 37214913
Cancer cells reprogram their metabolism to support cell growth and proliferation in harsh environments. While many studies have documented the importance of mitochondrial oxidative phosphorylation (OXPHOS) in tumor growth, some...
9.
Kaushik A, Tarangelo A, Boroughs L, Ragavan M, Zhang Y, Wu C, et al.
Sci Adv
. 2022 Dec;
8(50):eabp8293.
PMID: 36525494
Targeting metabolic vulnerabilities has been proposed as a therapeutic strategy in renal cell carcinoma (RCC). Here, we analyzed the metabolism of patient-derived xenografts (tumorgrafts) from diverse subtypes of RCC. Tumorgrafts...
10.
Pachnis P, Wu Z, Faubert B, Tasdogan A, Gu W, Shelton S, et al.
Sci Adv
. 2022 Aug;
8(35):eabn9550.
PMID: 36044570
In mice and humans with cancer, intravenous C-glucose infusion results in C labeling of tumor tricarboxylic acid (TCA) cycle intermediates, indicating that pyruvate oxidation in the TCA cycle occurs in...