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Laura Winchester

Explore the profile of Laura Winchester including associated specialties, affiliations and a list of published articles. Areas
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Articles 23
Citations 1028
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Recent Articles
1.
Ghose U, Sproviero W, Winchester L, Amin N, Zhu T, Newby D, et al.
Brief Bioinform . 2025 Jan; 26(1. PMID: 39775791
Augmenting traditional genome-wide association studies (GWAS) with advanced machine learning algorithms can allow the detection of novel signals in available cohorts. We introduce "genome-wide association neural networks (GWANN)" a novel...
2.
Smith R, Pishva E, Kouhsar M, Imm J, Dobricic V, Johannsen P, et al.
Alzheimers Dement . 2024 Aug; 20(10):6722-6739. PMID: 39193893
Introduction: We investigated blood DNA methylation patterns associated with 15 well-established cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) pathophysiology, neuroinflammation, and neurodegeneration. Methods: We assessed DNA methylation in 885...
3.
Argentieri M, Xiao S, Bennett D, Winchester L, Nevado-Holgado A, Ghose U, et al.
Nat Med . 2024 Aug; 30(9):2450-2460. PMID: 39117878
Circulating plasma proteins play key roles in human health and can potentially be used to measure biological age, allowing risk prediction for age-related diseases, multimorbidity and mortality. Here we developed...
4.
Pavarini G, Lyreskog D, Newby D, Lorimer J, Bennett V, Jacobs E, et al.
BMJ Ment Health . 2024 Mar; 27(1). PMID: 38508686
Background: Use of personal sensing to predict mental health risk has sparked interest in adolescent psychiatry, offering a potential tool for targeted early intervention. Objectives: We investigated the preferences and...
5.
Amin N, Liu J, Bonnechere B, Mahmoudiandehkordi S, Arnold M, Batra R, et al.
JAMA Psychiatry . 2023 Apr; 80(6):597-609. PMID: 37074710
Importance: Metabolomics reflect the net effect of genetic and environmental influences and thus provide a comprehensive approach to evaluating the pathogenesis of complex diseases, such as depression. Objective: To identify...
6.
Ranson J, Bucholc M, Lyall D, Newby D, Winchester L, Oxtoby N, et al.
Brain Inform . 2023 Feb; 10(1):6. PMID: 36829050
Progress in dementia research has been limited, with substantial gaps in our knowledge of targets for prevention, mechanisms for disease progression, and disease-modifying treatments. The growing availability of multimodal data...
7.
Winchester L, Barber I, Lawton M, Ash J, Liu B, Evetts S, et al.
Brain Commun . 2023 Jan; 5(1):fcac343. PMID: 36694577
Biomarkers to aid diagnosis and delineate the progression of Parkinson's disease are vital for targeting treatment in the early phases of the disease. Here, we aim to discover a multi-protein...
8.
Newby D, Linden A, Fernandes M, Molero Y, Winchester L, Sproviero W, et al.
BMJ Open Diabetes Res Care . 2022 Sep; 10(5). PMID: 36109050
Introduction: Type 2 diabetes is a risk factor for dementia and Parkinson's disease (PD). Drug treatments for diabetes, such as metformin, could be used as novel treatments for these neurological...
9.
Newby D, Winchester L, Sproviero W, Fernandes M, Ghose U, Lyall D, et al.
Brain Behav . 2022 Apr; 12(5):e2525. PMID: 35362209
Background: Hypertension is a well-established risk factor for cognitive impairment, brain atrophy, and dementia. However, the relationship of other types of hypertensions, such as isolated hypertension on brain health and...
10.
Li Z, Kormilitzin A, Fernandes M, Vaci N, Liu Q, Newby D, et al.
Int J Med Inform . 2022 Feb; 160:104704. PMID: 35168089
UK Biobank (UKB) is widely employed to investigate mental health disorders and related exposures; however, its applicability and relevance in a clinical setting and the assumptions required have not been...