Laura Torrente
Overview
Explore the profile of Laura Torrente including associated specialties, affiliations and a list of published articles.
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14
Citations
236
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Recent Articles
1.
Messina M, Torrente L, Pezacki A, Humpel H, Li E, Miller S, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(3):e2412816122.
PMID: 39813247
Copper is an essential nutrient for sustaining vital cellular processes spanning respiration, metabolism, and proliferation. However, loss of copper homeostasis, particularly misregulation of loosely bound copper ions which are defined...
2.
Greenwood H, Barber A, Edwards R, Tyrrell W, George M, Dos Santos S, et al.
Nat Commun
. 2024 Dec;
15(1):10484.
PMID: 39690148
Mutations in the NRF2-KEAP1 pathway are common in non-small cell lung cancer (NSCLC) and confer broad-spectrum therapeutic resistance, leading to poor outcomes. Currently, there is no means to non-invasively identify...
3.
Jiang Y, El Khoury E, Pezacki A, Qian N, Oi M, Torrente L, et al.
J Am Chem Soc
. 2024 Nov;
146(49):33324-33337.
PMID: 39586074
Molecular imaging with analyte-responsive probes offers a powerful chemical approach to studying biological processes. Many reagents for bioimaging employ a fluorescence readout, but the relatively broad emission bands of this...
4.
Pezacki A, Gonciarz R, Okamura T, Matier C, Torrente L, Cheng K, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(28):e2401579121.
PMID: 38968123
Iron is an essential element for life owing to its ability to participate in a diverse array of oxidation-reduction reactions. However, misregulation of iron-dependent redox cycling can also produce oxidative...
5.
Greenwood H, Edwards R, Tyrrell W, Barber A, Baark F, Tanc M, et al.
bioRxiv
. 2024 Jan;
PMID: 38168428
Mutations in the NRF2-KEAP1 pathway are common in non-small cell lung cancer (NSCLC) and confer broad-spectrum therapeutic resistance, leading to poor outcomes. The cystine/glutamate antiporter, system x, is one of...
6.
7.
Pezacki A, Matier C, Gu X, Kummelstedt E, Bond S, Torrente L, et al.
Proc Natl Acad Sci U S A
. 2022 Oct;
119(43):e2202736119.
PMID: 36252013
Copper is an essential metal nutrient for life that often relies on redox cycling between Cu(I) and Cu(II) oxidation states to fulfill its physiological roles, but alterations in cellular redox...
8.
Torrente L, DeNicola G
Annu Rev Pharmacol Toxicol
. 2021 Sep;
62:279-300.
PMID: 34499527
The transcription factor NRF2 coordinates the expression of a vast array of cytoprotective and metabolic genes in response to various stress inputs to restore cellular homeostasis. Transient activation of NRF2...
9.
Torrente L, Maan G, Oumkaltoum Rezig A, Quinn J, Jackson A, Grilli A, et al.
Biomolecules
. 2020 Sep;
10(10).
PMID: 32992842
Aberrant hyperactivation of nuclear factor erythroid 2 (NF-E2) p45-related factor 2 (NRF2) is a common event in many tumour types and associates with resistance to therapy and poor patient prognosis;...
10.
Torrente L, Prieto-Farigua N, Falzone A, Elkins C, Boothman D, Haura E, et al.
Redox Biol
. 2020 Feb;
30:101440.
PMID: 32007910
Alterations in the NRF2/KEAP1 pathway result in the constitutive activation of NRF2, leading to the aberrant induction of antioxidant and detoxification enzymes, including NQO1. The NQO1 bioactivatable agent β-lapachone can...