Donita C Brady
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Explore the profile of Donita C Brady including associated specialties, affiliations and a list of published articles.
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37
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2215
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Recent Articles
1.
Brady D
J Mol Biol
. 2025 Mar;
:169089.
PMID: 40089146
Dr. Donita C. Brady is the Harrison McCrea Dickson, MD, and Clifford C. Baker, MD Presidential Associate Professor of Cancer Biology at the University of Pennsylvania Perelman School of Medicine....
2.
Messina M, Torrente L, Pezacki A, Humpel H, Li E, Miller S, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(3):e2412816122.
PMID: 39813247
Copper is an essential nutrient for sustaining vital cellular processes spanning respiration, metabolism, and proliferation. However, loss of copper homeostasis, particularly misregulation of loosely bound copper ions which are defined...
3.
Lee J, Dilones S, Maujean T, Asad M, Mohd A, Auslander N, et al.
bioRxiv
. 2024 Aug;
PMID: 39091878
S-acyltransferases play integral roles in essential physiological processes including regulation of oncogenic signaling pathways. While discovered over 40 years ago the field still lacks specific S-acylation inhibitors thus the potential...
4.
Parham L, Williams P, Katada K, Nettleford S, Chatterji P, Acheampong K, et al.
Cell Mol Gastroenterol Hepatol
. 2023 Dec;
17(3):439-451.
PMID: 38081361
Background & Aims: The intestinal epithelium interfaces with a diverse milieu of luminal contents while maintaining robust digestive and barrier functions. Facultative intestinal stem cells are cells that survive tissue...
5.
6.
Dar A, Brady D
Mol Cell
. 2022 Nov;
82(22):4192-4193.
PMID: 36400004
Spencer-Smith et al. (2022) investigate multiple functions of the BRAF cysteine-rich domain (CRD), finding distinct classes of RASopathy-associated BRAF mutations and unique features among RAF paralogs that may contribute to...
7.
Pezacki A, Matier C, Gu X, Kummelstedt E, Bond S, Torrente L, et al.
Proc Natl Acad Sci U S A
. 2022 Oct;
119(43):e2202736119.
PMID: 36252013
Copper is an essential metal nutrient for life that often relies on redox cycling between Cu(I) and Cu(II) oxidation states to fulfill its physiological roles, but alterations in cellular redox...
8.
Chojnowski J, Li R, Tsang T, Alfaran F, Dick A, Cocklin S, et al.
Front Mol Biosci
. 2022 Jun;
9:878652.
PMID: 35755824
Casein kinase 2 (CK2) is an evolutionarily conserved serine/threonine kinase implicated in a wide range of cellular functions and known to be dysregulated in various diseases such as cancer. Compared...
9.
Cobine P, Brady D
Mol Cell
. 2022 May;
82(10):1786-1787.
PMID: 35594843
Tsvetkov et al. (2022) discovered a new form of cell death triggered by targeted accumulation of Cu in mitochondria that drives lipoylated TCA cycle enzyme aggregation via direct Cu binding.
10.
Doan M, Neinast M, Varner E, Bedi Jr K, Bartee D, Jiang H, et al.
J Lipid Res
. 2022 May;
63(6):100224.
PMID: 35568254
Anabolic metabolism of carbon in mammals is mediated via the one- and two-carbon carriers S-adenosyl methionine and acetyl-coenzyme A. In contrast, anabolic metabolism of three-carbon units via propionate has not...