Laura Maiorino
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Explore the profile of Laura Maiorino including associated specialties, affiliations and a list of published articles.
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31
Citations
2097
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Recent Articles
11.
Santollani L, Maiorino L, Zhang Y, Palmeri J, Stinson J, Duhamel L, et al.
Nat Immunol
. 2024 Aug;
25(10):1820-1829.
PMID: 39112631
Systemically administered cytokines are potent immunotherapeutics but can cause severe dose-limiting toxicities. To overcome this challenge, cytokines have been engineered for intratumoral retention after local delivery. However, despite inducing regression...
12.
Buckley M, Arainga M, Maiorino L, Pires I, Kim B, Michaels K, et al.
bioRxiv
. 2024 Jul;
PMID: 38979236
mRNA delivered using lipid nanoparticles (LNPs) has become an important subunit vaccine modality, but mechanisms of action for mRNA vaccines remain incompletely understood. Here, we synthesized a metal chelator-lipid conjugate...
13.
Pires I, Ni K, Melo M, Li N, Ben-Akiva E, Maiorino L, et al.
Chem Eng J
. 2024 May;
464.
PMID: 38737525
Immune stimulating complexes (ISCOMs) are safe and effective saponin-based adjuvants formed by the self-assembly of saponin, cholesterol, and phospholipids in water to form cage-like 30-40 nm diameter particles. Inclusion of...
14.
Barth N, Mendive-Tapia L, Subiros-Funosas R, Ghashghaei O, Lavilla R, Maiorino L, et al.
Angew Chem Weinheim Bergstr Ger
. 2024 Mar;
134(5):e202113020.
PMID: 38505298
The detection and quantification of apoptotic cells is a key process in cancer research, particularly during the screening of anticancer therapeutics and in mechanistic studies using preclinical models. Intravital optical...
15.
Santollani L, Zhang Y, Maiorino L, Palmeri J, Stinson J, Duhamel L, et al.
bioRxiv
. 2024 Jan;
PMID: 38260254
Cytokine therapies are potent immunotherapy agents but exhibit severe dose-limiting toxicities. One strategy to overcome this involves engineering cytokines for intratumoral retention following local delivery. Here, we develop a localized...
16.
Bhagchandani S, Yang L, Maiorino L, Ben-Akiva E, Rodrigues K, Romanov A, et al.
bioRxiv
. 2023 Dec;
PMID: 38045401
"Extended priming" immunization regimens that prolong exposure of the immune system to vaccines during the primary immune response have shown promise in enhancing humoral immune responses to a variety of...
17.
Phung I, Rodrigues K, Marina-Zarate E, Maiorino L, Pahar B, Lee W, et al.
Nat Commun
. 2023 Nov;
14(1):7107.
PMID: 37925510
Adjuvants and antigen delivery kinetics can profoundly influence B cell responses and should be critically considered in rational vaccine design, particularly for difficult neutralizing antibody targets such as human immunodeficiency...
18.
Ma L, Hostetler A, Morgan D, Maiorino L, Sulkaj I, Whittaker C, et al.
Cell
. 2023 Jul;
186(15):3148-3165.e20.
PMID: 37413990
Chimeric antigen receptor (CAR) T cell therapy effectively treats human cancer, but the loss of the antigen recognized by the CAR poses a major obstacle. We found that in vivo...
19.
Universal redirection of CAR T cells against solid tumours via membrane-inserted ligands for the CAR
Zhang A, Hostetler A, Chen L, Mukkamala V, Abraham W, Padilla L, et al.
Nat Biomed Eng
. 2023 Jun;
7(9):1113-1128.
PMID: 37291434
The effectiveness of chimaeric antigen receptor (CAR) T cell therapies for solid tumours is hindered by difficulties in the selection of an effective target antigen, owing to the heterogeneous expression...
20.
Aung A, Cui A, Maiorino L, Amini A, Gregory J, Bukenya M, et al.
Science
. 2023 Jan;
379(6630):eabn8934.
PMID: 36701450
The structural integrity of vaccine antigens is critical to the generation of protective antibody responses, but the impact of protease activity on vaccination in vivo is poorly understood. We characterized...