Kristen A Rodrigues
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Explore the profile of Kristen A Rodrigues including associated specialties, affiliations and a list of published articles.
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15
Citations
238
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Recent Articles
1.
Madden P, Marina-Zarate E, Rodrigues K, Steichen J, Shil M, Ni K, et al.
bioRxiv
. 2024 Dec;
PMID: 39651117
Rare B cells can have special pathogen-recognition features giving them the potential to make outsized contributions to protective immunity. However, rare naive B cells infrequently participate in immune responses. We...
2.
Bhagchandani S, Yang L, Lam J, Maiorino L, Ben-Akiva E, Rodrigues K, et al.
Sci Immunol
. 2024 Sep;
9(99):eadl3755.
PMID: 39303017
Prolonging exposure to subunit vaccines during the primary immune response enhances humoral immunity. Escalating-dose immunization (EDI), administering vaccines every other day in an increasing pattern over 2 weeks, is particularly...
3.
Rodrigues K, Zhang Y, Aung A, Morgan D, Maiorino L, Yousefpour P, et al.
bioRxiv
. 2024 Sep;
PMID: 39229011
Vaccines incorporating slow delivery, multivalent antigen display, or immunomodulation through adjuvants have an important role to play in shaping the humoral immune response. Here we analyzed mechanisms of action of...
4.
Edwards K, Schmidt K, Homad L, Kher G, Xu G, Rodrigues K, et al.
Cell Rep Med
. 2024 May;
5(6):101587.
PMID: 38781964
Epstein-Barr virus (EBV) is associated with infectious mononucleosis, cancer, and multiple sclerosis. A vaccine that prevents infection and/or EBV-associated morbidity is an unmet need. The viral gH/gL glycoprotein complex is...
5.
Pires I, Ni K, Melo M, Li N, Ben-Akiva E, Maiorino L, et al.
Chem Eng J
. 2024 May;
464.
PMID: 38737525
Immune stimulating complexes (ISCOMs) are safe and effective saponin-based adjuvants formed by the self-assembly of saponin, cholesterol, and phospholipids in water to form cage-like 30-40 nm diameter particles. Inclusion of...
6.
Bhagchandani S, Yang L, Maiorino L, Ben-Akiva E, Rodrigues K, Romanov A, et al.
bioRxiv
. 2023 Dec;
PMID: 38045401
"Extended priming" immunization regimens that prolong exposure of the immune system to vaccines during the primary immune response have shown promise in enhancing humoral immune responses to a variety of...
7.
Phung I, Rodrigues K, Marina-Zarate E, Maiorino L, Pahar B, Lee W, et al.
Nat Commun
. 2023 Nov;
14(1):7107.
PMID: 37925510
Adjuvants and antigen delivery kinetics can profoundly influence B cell responses and should be critically considered in rational vaccine design, particularly for difficult neutralizing antibody targets such as human immunodeficiency...
8.
Rodrigues K, Cottrell C, Steichen J, Groschel B, Abraham W, Suh H, et al.
NPJ Vaccines
. 2023 Aug;
8(1):117.
PMID: 37573422
In the ongoing effort to develop a vaccine against HIV, vaccine approaches that promote strong germinal center (GC) responses may be critical to enable the selection and affinity maturation of...
9.
Chang J, Agarwal Y, Rodrigues K, Momin N, Ni K, Read B, et al.
Adv Ther (Weinh)
. 2022 Oct;
5(7):2100235.
PMID: 36311814
Protein antigens are often combined with aluminum hydroxide (alum), the most commonly used adjuvant in licensed vaccines; yet the immunogenicity of alum-adjuvanted vaccines leaves much room for improvement. Here, the...
10.
Hartwell B, Melo M, Xiao P, Lemnios A, Li N, Chang J, et al.
Sci Transl Med
. 2022 Jul;
14(654):eabn1413.
PMID: 35857825
To combat the HIV epidemic and emerging threats such as SARS-CoV-2, immunization strategies are needed that elicit protection at mucosal portals of pathogen entry. Immunization directly through airway surfaces is...