Laura L Kiessling
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Explore the profile of Laura L Kiessling including associated specialties, affiliations and a list of published articles.
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164
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3914
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Recent Articles
1.
Ghosh S, Chorghade R, Diehl R, Dodge G, Bae S, Dugan A, et al.
bioRxiv
. 2025 Jan;
PMID: 39763805
Human lectins are critical carbohydrate-binding proteins that recognize diverse glycoconjugates from microorganisms and can play a key role in host-microbe interactions. Despite their importance in immune recognition and pathogen binding,...
2.
Syangtan D, Al Mahbuba D, Masuko S, Li Q, Elton A, Zaltsman Y, et al.
Stem Cell Reports
. 2024 Dec;
20(1):102384.
PMID: 39729990
Heparan sulfate (HS) is an anionic polysaccharide generated by all animal cells, but our understanding of its roles in human pluripotent stem cell (hPSC) self-renewal and differentiation is limited. We...
3.
Keys A, Kastner D, Kiessling L, Kulik H
Chem Sci
. 2024 Dec;
16(4):1746-1761.
PMID: 39669175
CH-π interactions between carbohydrates and aromatic amino acids play an essential role in biological systems that span all domains of life. Quantifying the strength and importance of these CH-π interactions...
4.
Lensch V, Johnson J, Kiessling L
Glycobiology
. 2024 Nov;
34(11).
PMID: 39593193
Central to immune recognition is the glycocalyx, a glycan-rich coat on all cells that plays a crucial role in interactions that enable pathogen detection and activation of immune defenses. Pathogens...
5.
Wang S, Shin T, Yoder 2nd H, McMillan R, Su H, Liu Y, et al.
Nat Methods
. 2024 Oct;
21(11):2128-2134.
PMID: 39394503
Expansion microscopy (ExM) is in increasingly widespread use throughout biology because its isotropic physical magnification enables nanoimaging on conventional microscopes. To date, ExM methods either expand specimens to a limited...
6.
Lensch V, Gabba A, Hincapie R, Bhagchandani S, Basak A, Alam M, et al.
ACS Nano
. 2024 Sep;
18(39):26770-26783.
PMID: 39283240
Cancer vaccine development is inhibited by a lack of strategies for directing dendritic cell (DC) induction of effective tumor-specific cellular immunity. Pathogen engagement of DC lectins and toll-like receptors (TLRs)...
7.
Diehl R, Chorghade R, Keys A, Alam M, Early S, Dugan A, et al.
JACS Au
. 2024 Aug;
4(8):3028-3037.
PMID: 39211619
Glycan-binding proteins, or lectins, recognize distinct structural elements of polysaccharides, to mediate myriad biological functions. Targeting glycan-binding proteins involved in human disease has been challenging due to an incomplete understanding...
8.
Wuo M, Dulberger C, Warner T, Brown R, Sturm A, Ultee E, et al.
J Am Chem Soc
. 2024 Jun;
146(26):17669-17678.
PMID: 38905328
The genus includes species such as , which can cause deadly human diseases. These bacteria have a protective cell envelope that can be remodeled to facilitate their survival in challenging...
9.
Tse M, Zhu M, Peters B, Hamami E, Chen J, Davis K, et al.
bioRxiv
. 2024 Apr;
PMID: 38585790
Antibiotic resistance, especially in multidrug-resistant ESKAPE pathogens, remains a worldwide problem. Combination antimicrobial therapies may be an important strategy to overcome resistance and broaden the spectrum of existing antibiotics. However,...
10.
Lensch V, Gabba A, Hincapie R, Bhagchandani S, Basak A, Alam M, et al.
bioRxiv
. 2024 Jan;
PMID: 38293025
Cancer vaccine development is inhibited by a lack of strategies for directing dendritic cell (DC) induction of effective tumor-specific cellular immunity. Pathogen engagement of DC lectins and toll-like receptors (TLRs)...