Laura L Grochowski
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Explore the profile of Laura L Grochowski including associated specialties, affiliations and a list of published articles.
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15
Citations
245
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Recent Articles
1.
Wang Y, Xu H, Grochowski L, White R
J Bacteriol
. 2014 Jul;
196(17):3191-8.
PMID: 24982305
The gene encoding 7,8-dihydroneopterin aldolase (DHNA) was recently identified in archaea through comparative genomics as being involved in methanopterin biosynthesis (V. Crécy-Lagard, G. Phillips, L. L. Grochowski, B. El Yacoubi,...
2.
de Crecy-Lagard V, Phillips G, Grochowski L, El Yacoubi B, Jenney F, Adams M, et al.
ACS Chem Biol
. 2012 Aug;
7(11):1807-16.
PMID: 22931285
C-1 carriers are essential cofactors in all domains of life, and in Archaea, these can be derivatives of tetrahydromethanopterin (H(4)-MPT) or tetrahydrofolate (H(4)-folate). Their synthesis requires 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) as...
3.
Grochowski L, Censky K, Xu H, White R
Arch Microbiol
. 2011 Oct;
194(2):141-5.
PMID: 22002406
The protein derived from the Methanocaldococcus jannaschii MJ0458 gene is annotated as a δ-1-pyrroline 5-carboxylate synthetase and is predicted to be related to aspartokinase and uridylate kinase. Analysis of the...
4.
Phillips G, Grochowski L, Bonnett S, Xu H, Bailly M, Blaby-Haas C, et al.
ACS Chem Biol
. 2011 Oct;
7(1):197-209.
PMID: 21999246
The biosynthesis of GTP derived metabolites such as tetrahydrofolate (THF), biopterin (BH(4)), and the modified tRNA nucleosides queuosine (Q) and archaeosine (G(+)) relies on several enzymes of the Tunnel-fold superfamily....
5.
Mashhadi Z, Xu H, Grochowski L, White R
Biochemistry
. 2010 Sep;
49(40):8748-55.
PMID: 20822113
FAD synthetases catalyze the transfer of the AMP portion of ATP to FMN to produce FAD and pyrophosphate (PP(i)). Monofunctional FAD synthetases exist in eukaryotes, while bacteria have bifunctional enzymes...
6.
Grochowski L, Xu H, White R
Biochemistry
. 2009 Mar;
48(19):4181-8.
PMID: 19309161
The early steps in the biosynthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (Fo) and riboflavin in the archaea differ from the established eukaryotic and bacterial pathways. The archaeal pathway has been proposed to begin...
7.
Grochowski L, Xu H, White R
Biochemistry
. 2008 Feb;
47(9):3033-7.
PMID: 18260642
Coenzyme F 420 is a hydride carrier cofactor functioning in methanogenesis. One step in the biosynthesis of coenzyme F 420 involves the coupling of 2-phospho- l-lactate (LP) to 7,8-didemethyl-8-hydroxy-5-deazaflavin, the...
8.
Forouhar F, Abashidze M, Xu H, Grochowski L, Seetharaman J, Hussain M, et al.
J Biol Chem
. 2008 Feb;
283(17):11832-40.
PMID: 18252724
Coenzyme F(420), a hydride carrier, is found in Archaea and some bacteria and has crucial roles in methanogenesis, antibiotic biosynthesis, DNA repair, and activation of antitubercular compounds. CofD, 2-phospho-l-lactate transferase,...
9.
Grochowski L, White R
Ann N Y Acad Sci
. 2007 Dec;
1125:190-214.
PMID: 18096851
The development of an oxygenated atmosphere on earth resulted in the polarization of life into two major groups, those that could live in the presence of oxygen and those that...
10.
Grochowski L, Xu H, Leung K, White R
Biochemistry
. 2007 May;
46(22):6658-67.
PMID: 17497938
The first step in the biosynthesis of pterins in bacteria and plants is the conversion of GTP to 7,8-dihydro-d-neopterin triphosphate catalyzed by GTP cyclohydrolase I (GTPCHI). Although GTP has been...