Laura Eckei
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Explore the profile of Laura Eckei including associated specialties, affiliations and a list of published articles.
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7
Citations
361
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Recent Articles
1.
Butepage M, Krieg S, Eckei L, Li J, Rossetti G, Verheugd P, et al.
Methods Mol Biol
. 2018 Aug;
1813:41-63.
PMID: 30097860
Mono-ADP-ribosylation is a posttranslational modification, which is catalyzed in cells by certain members of the ADP-ribosyltransferase diphtheria toxin-like family (ARTD) of ADP-ribosyltransferases (aka PARP enzymes). It involves the transfer of...
2.
Butepage M, Preisinger C, von Kriegsheim A, Scheufen A, Lausberg E, Li J, et al.
Sci Rep
. 2018 May;
8(1):6748.
PMID: 29712969
Macrodomains are conserved protein folds associated with ADP-ribose binding and turnover. ADP-ribosylation is a posttranslational modification catalyzed primarily by ARTD (aka PARP) enzymes in cells. ARTDs transfer either single or...
3.
Luscher B, Butepage M, Eckei L, Krieg S, Verheugd P, Shilton B
Chem Rev
. 2017 Nov;
118(3):1092-1136.
PMID: 29172462
Posttranslational modifications (PTMs) regulate protein functions and interactions. ADP-ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine dinucleotide (NAD) to modify target proteins with ADP-ribose. This modification can occur...
4.
Eckei L, Krieg S, Butepage M, Lehmann A, Gross A, Lippok B, et al.
Sci Rep
. 2017 Feb;
7:41746.
PMID: 28150709
Human pathogenic positive single strand RNA ((+)ssRNA) viruses, including Chikungunya virus, pose severe health problems as for many neither efficient vaccines nor therapeutic strategies exist. To interfere with propagation, viral...
5.
Verheugd P, Butepage M, Eckei L, Luscher B
Curr Protein Pept Sci
. 2016 Apr;
17(7):654-667.
PMID: 27090904
ADP-ribosylation describes an ancient and highly conserved posttranslational modification (PTM) of proteins. Many cellular processes have been identified that are regulated by ADP-ribosylation, including DNA repair, gene transcription and signaling...
6.
Butepage M, Eckei L, Verheugd P, Luscher B
Cells
. 2015 Oct;
4(4):569-95.
PMID: 26426055
A key process in the regulation of protein activities and thus cellular signaling pathways is the modification of proteins by post-translational mechanisms. Knowledge about the enzymes (writers and erasers) that...
7.
Fedorchenko O, Stiefelhagen M, Peer-Zada A, Barthel R, Mayer P, Eckei L, et al.
Blood
. 2013 Apr;
121(20):4126-36.
PMID: 23547049
The cell-surface glycoprotein CD44 is expressed in chronic lymphocytic leukemia (CLL), but its functional role in this disease is poorly characterized. We therefore investigated the contribution of CD44 to CLL...