Lasse Ebdrup Pedersen
Overview
Explore the profile of Lasse Ebdrup Pedersen including associated specialties, affiliations and a list of published articles.
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26
Citations
530
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Recent Articles
1.
Baek M, Kim C, Kim S, Karottki K, Hefzi H, Grav L, et al.
Metab Eng
. 2024 Nov;
87:11-20.
PMID: 39566816
Chinese hamster ovary (CHO) cells, which are widely used for therapeutic protein production, have been genetically manipulated to enhance productivity. Nearly half of the genes in CHO cells are silenced,...
2.
Mejias-Gomez O, Braghetto M, Sorensen M, Madsen A, Guiu L, Kristensen P, et al.
N Biotechnol
. 2024 Feb;
80:56-68.
PMID: 38354946
Antibody phage-display technology identifies antibody-antigen interactions through multiple panning rounds, but traditional screening gives no information on enrichment or diversity throughout the process. This results in the loss of valuable...
3.
Kim S, Shin S, Baek M, Xiong K, Karottki K, Hefzi H, et al.
Metab Eng
. 2023 Sep;
80:66-77.
PMID: 37709005
Chinese hamster ovary (CHO) cells are the preferred mammalian host cells for therapeutic protein production that have been extensively engineered to possess the desired attributes for high-yield protein production. However,...
4.
Xiong K, Karottki K, Hefzi H, Li S, Grav L, Li S, et al.
Cell Rep Methods
. 2022 Apr;
1(7):100115.
PMID: 35475003
[This corrects the article DOI: 10.1016/j.crmeth.2021.100062.].
5.
Stovicek V, Dato L, Almqvist H, Schopping M, Chekina K, Pedersen L, et al.
Biotechnol Biofuels Bioprod
. 2022 Feb;
15(1):22.
PMID: 35219341
Background: Lignosulfonates are significant wood chemicals with a $700 million market, produced by sulfite pulping of wood. During the pulping process, spent sulfite liquor (SSL) is generated, which in addition...
6.
Xiong K, Karottki K, Hefzi H, Li S, Grav L, Li S, et al.
Cell Rep Methods
. 2021 Dec;
1(4).
PMID: 34935002
Pooled CRISPR screens have been widely applied to mammalian and other organisms to elucidate the interplay between genes and phenotypes of interest. The most popular method for delivering the CRISPR...
7.
Zutz A, Hamborg L, Pedersen L, Kassem M, Papaleo E, Koza A, et al.
Nat Commun
. 2021 Oct;
12(1):6093.
PMID: 34667164
Strategies for investigating and optimizing the expression and folding of proteins for biotechnological and pharmaceutical purposes are in high demand. Here, we describe a dual-reporter biosensor system that simultaneously assesses...
8.
Hamborg L, Granata D, Olsen J, Roche J, Pedersen L, Nielsen A, et al.
Commun Biol
. 2021 Aug;
4(1):980.
PMID: 34408246
Most single point mutations destabilize folded proteins. Mutations that stabilize a protein typically only have a small effect and multiple mutations are often needed to substantially increase the stability. Multiple...
9.
Karottki K, Hefzi H, Li S, Pedersen L, Spahn P, Joshi C, et al.
Metab Eng
. 2021 Apr;
66:114-122.
PMID: 33813034
Media and feed optimization have fueled many-fold improvements in mammalian biopharmaceutical production, but genome editing offers an emerging avenue for further enhancing cell metabolism and bioproduction. However, the complexity of...
10.
Shin S, Kim S, Shin S, Grav L, Pedersen L, Lee J, et al.
ACS Synth Biol
. 2020 May;
9(6):1263-1269.
PMID: 32470292
Human cell lines are being increasingly used as host cells to produce therapeutic glycoproteins, due to their human glycosylation machinery. In an attempt to develop a platform for generating isogenic...