Alex Toftgaard Nielsen
Overview
Explore the profile of Alex Toftgaard Nielsen including associated specialties, affiliations and a list of published articles.
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Articles
42
Citations
1606
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Recent Articles
1.
Rong Y, Frey A, Ozdemir E, Sainz de la Maza Larrea A, Li S, Nielsen A, et al.
Nat Commun
. 2024 Oct;
15(1):8985.
PMID: 39420027
Replacing petrochemicals with compounds from bio-based manufacturing processes remains an important part of the global effort to move towards a sustainable future. However, achieving economic viability requires both optimized cell...
2.
Rong Y, Jensen S, Woodley J, Nielsen A
Biotechnol Bioeng
. 2024 Jul;
121(10):3001-3008.
PMID: 38970785
Bio-based production of fuels, chemicals and materials is needed to replace current fossil fuel based production. However, bio-based production processes are very costly, so the process needs to be as...
3.
Virklund A, Nielsen A, Woodley J
Chembiochem
. 2024 May;
25(19):e202400178.
PMID: 38742869
Natural and pure p-coumaric acid has valuable applications, and it can be produced via bioprocessing. However, fermentation processes have so far been unable to provide sufficient production metrics, while a...
4.
Gorter de Vries P, Mol V, Sonnenschein N, Jensen T, Nielsen A
Microb Biotechnol
. 2024 Feb;
17(2):e14414.
PMID: 38380934
Acetogenic gas fermentation is increasingly studied as a promising technology to upcycle carbon-rich waste gasses. Currently the product range is limited, and production yields, rates and titres for a number...
5.
Virklund A, Jendresen C, Nielsen A, Woodley J
Biotechnol J
. 2023 Jul;
18(11):e2300111.
PMID: 37486789
p-Coumaric acid (pCA) can be produced via bioprocessing and is a promising chemical precursor to making organic thin film transistors. However, the required tyrosine ammonia lyase (TAL) enzyme generally has...
6.
Millgaard M, Bidart G, Pogrebnyakov I, Nielsen A, Welner D
AMB Express
. 2023 May;
13(1):44.
PMID: 37154828
Parageobacillus thermoglucosidasius is a thermophilic Gram-positive bacterium, which is a promising host organism for sustainable bio-based production processes. However, to take full advantage of the potential of P. thermoglucosidasius, more...
7.
Rong Y, Jensen S, Lindorff-Larsen K, Nielsen A
Biotechnol Adv
. 2022 Dec;
63:108079.
PMID: 36528238
The expression of correctly folded and functional heterologous proteins is important in many biotechnological production processes, whether it is enzymes, biopharmaceuticals or biosynthetic pathways for production of sustainable chemicals. For...
8.
Kozaeva E, Mol V, Nikel P, Nielsen A
Microb Biotechnol
. 2022 Jun;
15(9):2426-2438.
PMID: 35689383
Randomized strain and pathway engineering are critical to improving microbial cell factory performance, calling for the development of high-throughput screening and selection systems. To facilitate this effort, we have developed...
9.
Falkenberg K, Mol V, Sainz de la Maza Larrea A, Pogrebnyakov I, Norholm M, Nielsen A, et al.
ACS Synth Biol
. 2021 Nov;
10(12):3278-3289.
PMID: 34793671
Versatile DNA assembly standards and compatible, well-characterized part libraries are essential tools for creating effective designs in synthetic biology. However, to date, vector standards for Gram-positive hosts have limited flexibility....
10.
Zutz A, Hamborg L, Pedersen L, Kassem M, Papaleo E, Koza A, et al.
Nat Commun
. 2021 Oct;
12(1):6093.
PMID: 34667164
Strategies for investigating and optimizing the expression and folding of proteins for biotechnological and pharmaceutical purposes are in high demand. Here, we describe a dual-reporter biosensor system that simultaneously assesses...