Lars Winkler
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Explore the profile of Lars Winkler including associated specialties, affiliations and a list of published articles.
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19
Citations
1081
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Recent Articles
1.
Ozistanbullu D, Wilhelm R, Reichenbach G, Doll M, Bahrami K, Zoller N, et al.
Blood Adv
. 2025 Feb;
PMID: 40020159
Cutaneous T-cell lymphomas (CTCL), including mycosis fungoides (MF) and Sézary syndrome (SS), are rare hematological malignancies with limited curative treatment options. Despite early-stage responsiveness, these malignancies often relapse in advanced...
2.
Specker E, Wesolowski R, Schutz A, Matthes S, Mallow K, Wasinska-Kalwa M, et al.
J Med Chem
. 2023 Oct;
66(21):14866-14896.
PMID: 37905925
Tryptophan hydroxylases catalyze the first and rate-limiting step in the biosynthesis of serotonin, a well-known neurotransmitter that plays an important role in multiple physiological functions. A reduction of serotonin levels,...
3.
Waldow A, Beier L, Arndt J, Schallenberg S, Vollbrecht C, Bischoff P, et al.
Pharmaceutics
. 2023 Jul;
15(7).
PMID: 37514167
Claudins regulate paracellular permeability, contribute to epithelial polarization and are dysregulated during inflammation and carcinogenesis. Variants of the claudin-binding domain of enterotoxin (cCPE) are highly sensitive protein ligands for generic...
4.
Alcaniz J, Winkler L, Dahlmann M, Becker M, Orthmann A, Haybaeck J, et al.
Front Oncol
. 2023 Apr;
13:1129627.
PMID: 37114125
Glioblastoma (GBM) heterogeneity, aggressiveness and infiltrative growth drastically limit success of current standard of care drugs and efficacy of various new therapeutic approaches. There is a need for new therapies...
5.
Breitkreuz-Korff O, Tscheik C, Del Vecchio G, Dithmer S, Walther W, Orthmann A, et al.
J Control Release
. 2021 Aug;
338:137-148.
PMID: 34384796
Drug delivery to the brain is limited for most pharmaceuticals by the blood-brain barrier (BBB) where claudin-5 dominates the paraendothelial tightening. For circumventing the BBB, we identified the compound M01...
6.
Schnurr M, Volk I, Nikolenko H, Winkler L, Dathe M, Schroder L
Adv Biosyst
. 2020 Apr;
4(3):e1900251.
PMID: 32293139
Improving diagnostic imaging and therapy by targeted compound delivery to pathological areas and across biological barriers is of urgent need. A lipopeptide, P-CrA-A2, composed of a highly cationic peptide sequence...
7.
Winkler L, Blasig R, Breitkreuz-Korff O, Berndt P, Dithmer S, Helms H, et al.
J Cereb Blood Flow Metab
. 2020 Feb;
41(1):132-145.
PMID: 32054373
The outcome of stroke is greatly influenced by the state of the blood-brain barrier (BBB). The BBB endothelium is sealed paracellularly by tight junction (TJ) proteins, i.e., claudins (Cldns) and...
8.
Berndt P, Winkler L, Cording J, Breitkreuz-Korff O, Rex A, Dithmer S, et al.
Cell Mol Life Sci
. 2019 Feb;
76(10):1987-2002.
PMID: 30734065
At the blood-brain barrier (BBB), claudin (Cldn)-5 is thought to be the dominant tight junction (TJ) protein, with minor contributions from Cldn3 and -12, and occludin. However, the BBB appears...
9.
Cording J, Arslan B, Staat C, Dithmer S, Krug S, Kruger A, et al.
Ann N Y Acad Sci
. 2017 Jun;
1405(1):89-101.
PMID: 28633193
The majority of tight junction (TJ) proteins restrict the paracellular permeation of solutes via their extracellular loops (ECLs). Tricellulin tightens tricellular TJs (tTJs) and regulates bicellular TJ (bTJ) proteins. We...
10.
Dithmer S, Staat C, Muller C, Ku M, Pohlmann A, Niendorf T, et al.
Ann N Y Acad Sci
. 2017 May;
1397(1):169-184.
PMID: 28505395
The blood-brain barrier (BBB) formed by the microvascular endothelium limits cerebral drug delivery. The paraendothelial cleft is sealed by tight junctions (TJs) with a major contribution from claudin-5, which we...