Lars Skjaerven
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Explore the profile of Lars Skjaerven including associated specialties, affiliations and a list of published articles.
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24
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701
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Recent Articles
1.
Grant B, Skjaerven L, Yao X
Protein Sci
. 2020 Aug;
30(1):20-30.
PMID: 32734663
Bio3D is a family of R packages for the analysis of biomolecular sequence, structure, and dynamics. Major functionality includes biomolecular database searching and retrieval, sequence and structure conservation analysis, ensemble...
2.
Grant B, Skjaerven L, Yao X
Methods Mol Biol
. 2020 Feb;
2112:15-28.
PMID: 32006275
Bio3D-web is an online application for the interactive analysis of sequence-structure-dynamics relationships in user-defined protein structure sets. Major functionality includes structure database searching, sequence and structure conservation assessment, inter-conformer relationship...
3.
Bustad H, Toska K, Schmitt C, Vorland M, Skjaerven L, Kallio J, et al.
Mol Ther
. 2019 Dec;
28(2):677-689.
PMID: 31810863
Mutations in hydroxymethylbilane synthase (HMBS) cause acute intermittent porphyria (AIP), an autosomal dominant disease where typically only one HMBS allele is mutated. In AIP, the accumulation of porphyrin precursors triggers...
4.
Flydal M, Alcorlo-Pages M, Johannessen F, Martinez-Caballero S, Skjaerven L, Fernandez-Leiro R, et al.
Proc Natl Acad Sci U S A
. 2019 May;
116(23):11229-11234.
PMID: 31118288
Phenylalanine hydroxylase (PAH) is a key enzyme in the catabolism of phenylalanine, and mutations in this enzyme cause phenylketonuria (PKU), a genetic disorder that leads to brain damage and mental...
5.
Jimenez A, Jonic S, Majtner T, Oton J, Vilas J, Maluenda D, et al.
Bioinformatics
. 2018 Dec;
35(14):2427-2433.
PMID: 30500892
Motivation: Cryo electron microscopy (EM) is currently one of the main tools to reveal the structural information of biological macromolecules. The re-construction of three-dimensional (3D) maps is typically carried out...
6.
Urbaneja M, Skjaerven L, Aubi O, Underhaug J, Lopez D, Arregi I, et al.
Sci Rep
. 2017 Oct;
7(1):13959.
PMID: 29066752
Nucleophosmin (NPM) is a nucleolar protein involved in ribosome assembly and cell homeostasis. Mutations in the C-terminal domain of NPM that impair native folding and localization are associated with acute...
7.
Jariwala S, Skjaerven L, Yao X, Grant B
J Vis Exp
. 2017 Jul;
(125).
PMID: 28745621
We demonstrate the usage of Bio3D-web for the interactive analysis of biomolecular structure data. The Bio3D-web application provides online functionality for: (1) The identification of related protein structure sets to...
8.
Stable preparations of tyrosine hydroxylase provide the solution structure of the full-length enzyme
Bezem M, Baumann A, Skjaerven L, Meyer R, Kursula P, Martinez A, et al.
Sci Rep
. 2016 Jul;
6:30390.
PMID: 27462005
Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of catecholamine neurotransmitters. TH is a highly complex enzyme at mechanistic, structural, and regulatory levels, and the preparation of kinetically...
9.
Skjaerven L, Jariwala S, Yao X, Grant B
Bioinformatics
. 2016 Jul;
32(22):3510-3512.
PMID: 27423893
Availability: Bio3D-web is based on the Bio3D and Shiny R packages. All major browsers are supported and full source code is available under a GPL2 license from http://thegrantlab.org/bio3d-web CONTACT: bjgrant@umich.edu...
10.
Yao X, Skjaerven L, Grant B
J Phys Chem B
. 2016 Apr;
120(33):8276-88.
PMID: 27056373
Allosteric regulation is a primary means of controlling protein function. By definition, allostery involves the propagation of structural dynamic changes between distal protein sites that yields a functional change. Gaining...