Lars Piepkorn
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Explore the profile of Lars Piepkorn including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
135
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Recent Articles
1.
Siems S, Gargareta V, Schadt L, Daguano Gastaldi V, Jung R, Piepkorn L, et al.
Glia
. 2024 Sep;
73(1):38-56.
PMID: 39344832
The molecules that constitute myelin are critical for the integrity of axon/myelin-units and thus speed and precision of impulse propagation. In the CNS, the protein composition of oligodendrocyte-derived myelin has...
2.
Chatterjee M, Ozdemir S, Kunadt M, Koel-Simmelink M, Boiten W, Piepkorn L, et al.
Alzheimers Dement
. 2023 Apr;
19(11):4828-4840.
PMID: 37023079
Introduction: Extracellular vesicles (EVs) may propagate and modulate Alzheimer's disease (AD) pathology. We aimed to comprehensively characterize the proteome of cerebrospinal fluid (CSF) EVs to identify proteins and pathways altered...
3.
Duking T, Spieth L, Berghoff S, Piepkorn L, Schmidke A, Mitkovski M, et al.
Sci Adv
. 2022 Sep;
8(37):eabo7639.
PMID: 36112685
To maintain homeostasis, the body, including the brain, reprograms its metabolism in response to altered nutrition or disease. However, the consequences of these challenges for the energy metabolism of the...
4.
Gargareta V, Reuschenbach J, Siems S, Sun T, Piepkorn L, Mangana C, et al.
Elife
. 2022 May;
11.
PMID: 35543322
Human myelin disorders are commonly studied in mouse models. Since both clades evolutionarily diverged approximately 85 million years ago, it is critical to know to what extent the myelin protein...
5.
Meschkat M, Steyer A, Weil M, Kusch K, Jahn O, Piepkorn L, et al.
Nat Commun
. 2022 Mar;
13(1):1163.
PMID: 35246535
Myelin, the electrically insulating sheath on axons, undergoes dynamic changes over time. However, it is composed of proteins with long lifetimes. This raises the question how such a stable structure...
6.
Ambrozkiewicz M, Borisova E, Schwark M, Ripamonti S, Schaub T, Smorodchenko A, et al.
Mol Psychiatry
. 2020 Apr;
26(6):1980-1995.
PMID: 32249816
Kaufman oculocerebrofacial syndrome (KOS) is a severe autosomal recessive disorder characterized by intellectual disability, developmental delays, microcephaly, and characteristic dysmorphisms. Biallelic mutations of UBE3B, encoding for a ubiquitin ligase E3B...
7.
Ambrozkiewicz M, Schwark M, Kishimoto-Suga M, Borisova E, Hori K, Salazar-Lazaro A, et al.
Neuron
. 2018 Nov;
100(5):1097-1115.e15.
PMID: 30392800
The establishment of axon-dendrite polarity is fundamental for radial migration of neurons during cortex development of mammals. We demonstrate that the E3 ubiquitin ligases WW-Containing Proteins 1 and 2 (Wwp1...
8.
Stankova T, Piepkorn L, Bayer T, Jahn O, Tirard M
Aging Cell
. 2018 Apr;
17(4):e12760.
PMID: 29633471
A proper equilibrium of post-translational protein modifications is essential for normal cell physiology, and alteration in these processes is key in neurodegenerative disorders such as Alzheimer's disease. Recently, for instance,...