Lars Maegdefessel
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Explore the profile of Lars Maegdefessel including associated specialties, affiliations and a list of published articles.
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176
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4960
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Recent Articles
1.
El Bounkari O, Zan C, Yang B, Ebert S, Wagner J, Bugar E, et al.
Nat Commun
. 2025 Mar;
16(1):2297.
PMID: 40055309
Atherosclerosis is the underlying cause of myocardial infarction and ischemic stroke. It is a lipid-triggered and cytokine/chemokine-driven arterial inflammatory condition. We identify D-dopachrome tautomerase/macrophage migration-inhibitory factor-2 (MIF-2), a paralog of...
2.
Tan J, Cheng L, Calhoun R, Weller A, Drareni K, Fong S, et al.
bioRxiv
. 2025 Mar;
PMID: 40027729
Vascular smooth muscle cells (SMCs) normally exist in a contractile state but can undergo fate switching to produce various cell phenotypes in response to pathologic stimuli. In atherosclerosis, these phenotypically...
3.
Parma L, Sachs N, Sobczak N, Li Z, Merchant K, Pauli J, et al.
Circulation
. 2025 Feb;
151(8):581-584.
PMID: 39993040
No abstract available.
4.
Bonfiglio C, Lacy M, Triantafyllidou V, Farina F, Janjic A, Nitz K, et al.
Circulation
. 2025 Feb;
PMID: 39917842
Background: The activation and polarization of T cells play a crucial role in atherosclerosis and dictate athero-inflammation. The epigenetic enzyme EZH2 (enhancer of zeste homolog 2) mediates the H3K27me3 (trimethylation...
5.
Northoff B, Herbst A, Wenk C, Weindl L, Gabel G, Brezski A, et al.
Cardiovasc Res
. 2025 Feb;
PMID: 39901821
Aims: The role of circular RNAs (circRNAs) and their regulation in health and disease are poorly understood. Here, we systematically investigated the temporally resolved transcriptomic expression of circRNAs during differentiation...
6.
Sopic M, Karaduzovic-Hadziabdic K, Kardassis D, Maegdefessel L, Martelli F, Meerson A, et al.
J Mol Cell Cardiol Plus
. 2025 Jan;
6():100048.
PMID: 39802625
Atherosclerotic disease is a major cause of acute cardiovascular events. A deeper understanding of its underlying mechanisms will allow advancing personalized and patient-centered healthcare. Transcriptomic research has proven to be...
7.
Maegdefessel L, Fasolo F
Arterioscler Thromb Vasc Biol
. 2024 Dec;
45(2):172-185.
PMID: 39633574
In the healthy mature artery, vascular cells, including endothelial cells, smooth muscle cells (SMCs), and fibroblasts are organized in different layers, performing specific functions. SMCs located in the media are...
8.
Liu W, Hardaway B, Kim E, Pauli J, Wettich J, Yalcinkaya M, et al.
J Clin Invest
. 2024 Nov;
135(1).
PMID: 39531316
Clonal hematopoiesis (CH) increases inflammasome-linked atherosclerosis, but the mechanisms by which CH mutant cells transmit inflammatory signals to nonmutant cells are largely unknown. To address this question, we transplanted 1.5%...
9.
Kontidou E, Humoud R, Chernogubova E, Alvarsson M, Maegdefessel L, Collado A, et al.
Am J Physiol Heart Circ Physiol
. 2024 Oct;
327(5):H1296-H1302.
PMID: 39422364
microRNAs (miRNAs) have been intensively studied as valuable biomarkers in cardiometabolic disease. Typically, miRNAs are detected in plasma or serum, but the use of samples collected in heparinized tubes is...
10.
Bamezai S, Zhang Y, Kumari M, Lotfi M, Alsaigh T, Luo L, et al.
Nat Commun
. 2024 Sep;
15(1):8034.
PMID: 39271657
Atherosclerosis is an inflammatory disorder responsible for cardiovascular disease. Reactivation of efferocytosis, the phagocytic removal of cells by macrophages, has emerged as a translational target for atherosclerosis. Systemic blockade of...