Lars Bohlin
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Explore the profile of Lars Bohlin including associated specialties, affiliations and a list of published articles.
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52
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945
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Recent Articles
11.
Sjogren M, Jonsson P, Dahlstrom M, Lundalv T, Burman R, Goransson U, et al.
J Nat Prod
. 2011 Feb;
74(3):449-54.
PMID: 21338120
The current work shows that two structurally similar cyclodipeptides, barettin (1) and 8,9-dihydrobarettin (2), produced by the coldwater marine sponge Geodia barretti Bowerbank act in synergy to deter larvae of...
12.
Hallbook H, Felth J, Eriksson A, Fryknas M, Bohlin L, Larsson R, et al.
PLoS One
. 2011 Jan;
6(1):e15718.
PMID: 21246039
Background: Despite years of interest in the anti-cancerous effects of cardiac glycosides (CGs), and numerous studies in vitro and in animals, it has not yet been possible to utilize this...
13.
Roggen H, Charnock C, Burman R, Felth J, Larsson R, Bohlin L, et al.
Arch Pharm (Weinheim)
. 2011 Jan;
344(1):50-5.
PMID: 21213351
Agelasines are 7,9-dialkylpurinium salts found in marine sponges (Agelas sp.), which display a variety of antimicrobial and cytotoxic effects. We have synthesized simplified agelasine analogs modified in the purine 2-position...
14.
Bohlin L, Goransson U, Alsmark C, Weden C, Backlund A
Phytochem Rev
. 2010 Aug;
9(2):279-301.
PMID: 20700376
With a realistic threat against biodiversity in rain forests and in the sea, a sustainable use of natural products is becoming more and more important. Basic research directed against different...
15.
Gerlach S, Burman R, Bohlin L, Mondal D, Goransson U
J Nat Prod
. 2010 Jun;
73(7):1207-13.
PMID: 20575512
Cyclotides, the largest known family of head-to-tail cyclic peptides, have approximately 30 amino acid residues with a complex structure containing a circular peptide backbone and a cystine knot. They are...
16.
Burman R, Svedlund E, Felth J, Hassan S, Herrmann A, Clark R, et al.
Biopolymers
. 2010 Jun;
94(5):626-34.
PMID: 20564012
Cycloviolacin O2 is a small cyclic cysteine-rich protein belonging to the group of plant proteins called cyclotides. This cyclotide has been previously shown to exert cytotoxic activity against a variety...
17.
Felth J, Rickardson L, Rosen J, Wickstrom M, Fryknas M, Lindskog M, et al.
J Nat Prod
. 2009 Nov;
72(11):1969-74.
PMID: 19894733
Cardiac glycosides have been reported to exhibit cytotoxic activity against several different cancer types, but studies against colorectal cancer are lacking. In a screening procedure aimed at identifying natural products...
18.
Wang C, Hu S, Martin J, Sjogren T, Hajdu J, Bohlin L, et al.
J Biol Chem
. 2009 Feb;
284(16):10672-83.
PMID: 19211551
Cyclotides are a family of plant defense proteins that are highly resistant to adverse chemical, thermal, and enzymatic treatment. Here, we present the first crystal structure of a cyclotide, varv...
19.
Ekenas C, Zebrowska A, Schuler B, Vrede T, Andreasen K, Backlund A, et al.
Planta Med
. 2008 Nov;
74(15):1789-94.
PMID: 18975264
Several species in the genus Arnica have been used in traditional medicine to treat inflammatory-related disorders. Extracts of twelve Arnica species and two species closely related to arnica ( Layia...
20.
Pettersson J, Karlsson P, Choi Y, Verpoorte R, Rafter J, Bohlin L
Biol Pharm Bull
. 2008 Jun;
31(6):1192-8.
PMID: 18520053
A vegetarian diet rich in phytochemicals may prevent colon carcinogenesis by affecting biochemical processes in the colonic mucosa. Compounds passing the digestive system reaching the colon could potentially be detected...