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Lars Bertram

Explore the profile of Lars Bertram including associated specialties, affiliations and a list of published articles. Areas
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Articles 245
Citations 14576
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Recent Articles
1.
Wesenhagen K, de Leeuw D, Tomassen J, Gobom J, Bos I, Vos S, et al.
Alzheimers Res Ther . 2025 Mar; 17(1):56. PMID: 40033427
Background: We investigated how cerebrospinal fluid levels of synaptic proteins associate with memory function in normal cognition (CN) and mild cognitive impairment (MCI), and investigated the effect of amyloid positivity...
2.
Deecke L, Ohlei O, Goldeck D, Homann J, Toepfer S, Demuth I, et al.
Cells . 2025 Feb; 14(4). PMID: 39996723
The immune system plays a crucial role in the pathogenesis of neurodegenerative diseases. Here, we explored whether blood immune cell profiles are already altered in healthy individuals with a genetic...
3.
Castanho I, Yeganeh P, Boix C, Morgan S, Mathys H, Prokopenko D, et al.
bioRxiv . 2025 Jan; PMID: 39868232
Background: A significant proportion of individuals maintain healthy cognitive function despite having extensive Alzheimer's disease (AD) pathology, known as cognitive resilience. Understanding the molecular mechanisms that protect these individuals can...
4.
Deecke L, Goldeck D, Ohlei O, Homann J, Demuth I, Bertram L, et al.
Int J Mol Sci . 2025 Jan; 25(24. PMID: 39769417
The immune system likely plays a key role in Parkinson's disease (PD) pathophysiology. Thus, we investigated whether immune cell compositions are already altered in healthy individuals at high genetic risk...
5.
Roe J, Vidal-Pineiro D, Sorensen O, Grydeland H, Leonardsen E, Iakunchykova O, et al.
Nat Commun . 2024 Dec; 15(1):10651. PMID: 39690174
Throughout adulthood and ageing our brains undergo structural loss in an average pattern resembling faster atrophy in Alzheimer's disease (AD). Using a longitudinal adult lifespan sample (aged 30-89; 2-7 timepoints)...
6.
Drewelies J, Homann J, Vetter V, Duezel S, Kuhn S, Deecke L, et al.
J Gerontol A Biol Sci Med Sci . 2024 Oct; PMID: 39383103
Aging is a complex process influenced by mechanisms operating at numerous levels of functioning. Multiple biomarkers of age have been identified, yet we know little about how the different alternative...
7.
Koetsier J, Cavill R, Reijnders R, Harvey J, Homann J, Kouhsar M, et al.
Alzheimers Dement . 2024 Aug; 20(10):6682-6698. PMID: 39193899
Introduction: The established link between DNA methylation and pathophysiology of dementia, along with its potential role as a molecular mediator of lifestyle and environmental influences, positions blood-derived DNA methylation as...
8.
Smith R, Pishva E, Kouhsar M, Imm J, Dobricic V, Johannsen P, et al.
Alzheimers Dement . 2024 Aug; 20(10):6722-6739. PMID: 39193893
Introduction: We investigated blood DNA methylation patterns associated with 15 well-established cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) pathophysiology, neuroinflammation, and neurodegeneration. Methods: We assessed DNA methylation in 885...
9.
Wesenhagen K, de Leeuw D, Tomassen J, Gobom J, Bos I, Vos S, et al.
Res Sq . 2024 Aug; PMID: 39108495
Introduction: We investigated how cerebrospinal fluid levels of synaptic proteins associate with memory function in normal cognition (CN) and mild cognitive impairment (MCI), and investigated the effect of amyloid positivity...
10.
Song C, Ohlei O, Keller T, Regitz-Zagrosek V, Toepfer S, Steinhagen-Thiessen E, et al.
Biomedicines . 2024 Jul; 12(7). PMID: 39062075
While numerous studies have confirmed a causal association between lipoprotein(a) [Lp(a)] and cardiovascular diseases, only a few studies have assessed the relationship between Lp(a) and pulmonary health, with inconsistent findings...