Larry S Tobacman
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Explore the profile of Larry S Tobacman including associated specialties, affiliations and a list of published articles.
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28
Citations
1135
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Recent Articles
1.
Tobacman L, Cammarato A
J Gen Physiol
. 2021 Jan;
153(3).
PMID: 33492345
Reversible Ca2+ binding to troponin is the primary on-off switch of the contractile apparatus of striated muscles, including the heart. Dominant missense mutations in human cardiac troponin genes are among...
2.
Tobacman L
Biophys J
. 2020 Nov;
120(1):1-9.
PMID: 33221250
Recently, our understanding of the structural basis of troponin-tropomyosin's Ca-triggered regulation of striated muscle contraction has advanced greatly, particularly via cryo-electron microscopy data. Compelling atomic models of troponin-tropomyosin-actin were published...
3.
Madan A, Viswanathan M, Woulfe K, Schmidt W, Sidor A, Liu T, et al.
Proc Natl Acad Sci U S A
. 2020 Jul;
117(31):18822-18831.
PMID: 32690703
Muscle contraction is regulated by the movement of end-to-end-linked troponin-tropomyosin complexes over the thin filament surface, which uncovers or blocks myosin binding sites along F-actin. The N-terminal half of troponin...
4.
Mun J, Previs M, Yu H, Gulick J, Tobacman L, Previs S, et al.
Proc Natl Acad Sci U S A
. 2014 Jan;
111(6):2170-5.
PMID: 24477690
Myosin-binding protein C (MyBP-C) is an accessory protein of striated muscle thick filaments and a modulator of cardiac muscle contraction. Defects in the cardiac isoform, cMyBP-C, cause heart disease. cMyBP-C...
5.
Kowlessur D, Tobacman L
J Biol Chem
. 2012 Oct;
287(50):42299-311.
PMID: 23066014
Ca(2+) dissociation from troponin causes cessation of muscle contraction by incompletely understood structural mechanisms. To investigate this process, regulatory site Ca(2+) binding in the NH(2)-lobe of subunit troponin C (TnC)...
6.
Li X, Tobacman L, Mun J, Craig R, Fischer S, Lehman W
Biophys J
. 2011 Feb;
100(4):1005-13.
PMID: 21320445
Electron microscopy and fiber diffraction studies of reconstituted F-actin-tropomyosin filaments reveal the azimuthal position of end-to-end linked tropomyosin molecules on the surface of actin. However, the longitudinal z-position of tropomyosin...
7.
Ali L, Cohen J, Tobacman L
Biochemistry
. 2010 Dec;
49(51):10873-80.
PMID: 21114337
Tropomyosin is a ubiquitous actin-binding protein with an extended coiled-coil structure. Tropomyosin-actin interactions are weak and loosely specific, but they potently influence myosin. One such influence is inhibitory and is...
8.
Kozaili J, Leek D, Tobacman L
J Biol Chem
. 2010 Oct;
285(49):38034-41.
PMID: 20889978
Striated muscles are relaxed under low Ca(2+) concentration conditions due to actions of the thin filament protein troponin. To investigate this regulatory mechanism, an 11-residue segment of cardiac troponin I...
9.
Kowlessur D, Tobacman L
J Biol Chem
. 2010 Oct;
285(50):38978-86.
PMID: 20889975
Troponin is a pivotal regulatory protein that binds Ca(2+) reversibly to act as the muscle contraction on-off switch. To understand troponin function, the dynamic behavior of the Ca(2+)-saturated cardiac troponin...
10.
Sousa D, Cammarato A, Jang K, Graceffa P, Tobacman L, Li X, et al.
Biophys J
. 2010 Aug;
99(3):862-8.
PMID: 20682264
The structural mechanics of tropomyosin are essential determinants of its affinity and positioning on F-actin. Thus, tissue-specific differences among tropomyosin isoforms may influence both access of actin-binding proteins along the...