Larry N Agbor
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Explore the profile of Larry N Agbor including associated specialties, affiliations and a list of published articles.
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19
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402
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Recent Articles
1.
Wu J, Fang S, Lu K, Kumar G, Reho J, Brozoski D, et al.
Function (Oxf)
. 2022 May;
3(3):zqac017.
PMID: 35493997
Human hypertension caused by in-frame deletion of exon-9 (Cul3∆9) is driven by renal and vascular mechanisms. We bred conditionally activatable Cul3∆9 transgenic mice with tamoxifen-inducible Tie2-CRE mice to test the...
2.
Nakagawa P, Nair A, Agbor L, Gomez J, Wu J, Zhang S, et al.
Hypertension
. 2020 Jun;
76(2):468-477.
PMID: 32507043
Several cardiac and renal diseases are attributed to a dysregulation of the renin-angiotensin system. Renin, the rate-limiting enzyme of the renin-angiotensin system, has 2 isoforms. The classical renin isoform (renin-a)...
3.
Wu J, Agbor L, Fang S, Mukohda M, Nair A, Nakagawa P, et al.
Cardiovasc Res
. 2020 May;
117(1):308-319.
PMID: 32428209
Aims: Salt-sensitive (SS) hypertension is accompanied by impaired vasodilation in the systemic and renal circulation. However, the causal relationship between vascular dysfunction and salt-induced hypertension remains controversial. We sought to...
4.
Davidge B, Rebola K, Agbor L, Sigmund C, Singer J
J Cell Sci
. 2019 Oct;
132(21).
PMID: 31636116
Cyclin E and its binding partner Cdk2 control the G1/S transition in mammalian cells. Increased levels of cyclin E are found in some cancers. Additionally, proteolytic removal of the cyclin...
5.
Agbor L, Nair A, Wu J, Lu K, Davis D, Keen H, et al.
JCI Insight
. 2019 Jun;
5.
PMID: 31184598
Patients with mutations in Cullin-3 (CUL3) exhibit severe early onset hypertension but the contribution of the smooth muscle remains unclear. Conditional genetic ablation of CUL3 in vascular smooth muscle (S-CUL3KO)...
6.
Nair A, Silva Jr S, Agbor L, Wu J, Nakagawa P, Mukohda M, et al.
Hypertension
. 2019 May;
74(1):173-183.
PMID: 31104564
Preeclampsia is a hypertensive disorder of pregnancy associated with vascular dysfunction and cardiovascular risk to offspring. We hypothesize that endothelial PPARγ (peroxisome proliferator-activated receptor-γ) provides cardiovascular protection in offspring from...
7.
Mukohda M, Fang S, Wu J, Agbor L, Nair A, Ibeawuchi S, et al.
J Clin Invest
. 2019 Mar;
129(6):2318-2332.
PMID: 30896450
Mice selectively expressing PPARγ dominant negative mutation in vascular smooth muscle exhibit RhoBTB1-deficiency and hypertension. Our rationale was to employ genetic complementation to uncover the mechanism of action of RhoBTB1...
8.
Nair A, Agbor L, Mukohda M, Liu X, Hu C, Wu J, et al.
Hypertension
. 2018 Oct;
72(5):1227-1235.
PMID: 30354810
Low-salt diet is beneficial in salt-sensitive hypertension but may provoke cardiovascular risk in patients with heart failure, diabetes mellitus, or other cardiovascular abnormalities because of endogenous renin-angiotensin system activation. PPAR...
9.
Sandgren J, Deng G, Linggonegoro D, Scroggins S, Perschbacher K, Nair A, et al.
JCI Insight
. 2018 Oct;
3(19).
PMID: 30282823
Copeptin, a marker of arginine vasopressin (AVP) secretion, is elevated throughout human pregnancies complicated by preeclampsia (PE), and AVP infusion throughout gestation is sufficient to induce the major phenotypes of...
10.
Cornelius R, Zhang C, Erspamer K, Agbor L, Sigmund C, Singer J, et al.
Am J Physiol Renal Physiol
. 2018 Jun;
315(4):F1006-F1018.
PMID: 29897280
Familial hyperkalemic hypertension is caused by mutations in with-no-lysine kinases (WNKs) or in proteins that mediate their degradation, kelch-like 3 (KLHL3) and cullin 3 (CUL3). Although the mechanisms by which...